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Pinlyp Gene Detail
Summary
  • Symbol
    Pinlyp
  • Name
    phospholipase A2 inhibitor and LY6/PLAUR domain containing
  • Synonyms
    2310033E01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3615324
    NCBI Gene: 641361
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:24241083-24245543 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 11.38 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    170 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3615324
 protein coding gene Chr7:24241079-24246045 (-)
129S1/SvImJ ENSMUSG00200040497
 protein coding gene Chr7:14244109-14248569 (-)
A/J ENSMUSG00195048717
 protein coding gene Chr7:16680865-16685326 (-)
AKR/J ENSMUSG00220047185
 protein coding gene Chr7:27705247-27709710 (+)
BALB/cJ ENSMUSG00180053641
 protein coding gene Chr7:14752858-14757320 (-)
C3H/HeJ ENSMUSG00175046574
 protein coding gene Chr7:15802895-15807311 (-)
C57BL/6NJ ENSMUSG00215052172
 protein coding gene Chr7:14156842-14161303 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029339
 protein coding gene Chr7:23814169-23818705 (-)
CAST/EiJ ENSTCUG00005052328
 protein coding gene Chr7:15850832-15855311 (-)
CBA/J ENSMUSG00210051967
 protein coding gene Chr7:14988629-14993045 (-)
DBA/2J ENSMUSG00185051258
 protein coding gene Chr7:18196538-18200998 (-)
FVB/NJ ENSMUSG00205024533
 protein coding gene Chr7:14993323-14997783 (-)
JF1/MsJ ENSUMUG00000044599
 protein coding gene Chr7:22498457-22502873 (-)
LP/J ENSMUSG00230052321
 protein coding gene Chr7:23470471-23474930 (-)
NOD/ShiLtJ ENSMUSG00190045398
 protein coding gene Chr7:14470349-14474765 (-)
NZO/HlLtJ ENSMUSG00225023766
 protein coding gene Chr7:22138347-22142806 (-)
PWK/PhJ ENSLUMG00010050800
 protein coding gene Chr7:14432490-14436947 (-)
SPRET/EiJ ENSMSPG00010050294
 protein coding gene Chr7:14092487-14096983 (-)
WSB/EiJ ENSIUOG00005051502
 protein coding gene Chr7:8929771-8934191 (-)



Homology
more
  • Human Ortholog
    PINLYP, phospholipase A2 inhibitor and LY6/PLAUR domain containing
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PINLYP, phospholipase A2 inhibitor and LY6/PLAUR domain containing
  • Links
    NCBI Gene ID: 390940
    UniProt: A6NC86

  • Chr Location
    19q13.31; chr19:43575509-43583964 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a mutation are viable and show normal fertility. Mice homozygous for a null allele display embryonic lethality during organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    16
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000011632 Ensembl Gene Model | MGI Sequence Detail 4461 C57BL/6J ±  kb
transcript ENSMUST00000011776 Ensembl | MGI Sequence Detail 843 Not Applicable  
polypeptide ENSMUSP00000011776 Ensembl | MGI Sequence Detail 212 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000031518 phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein
    (term hierarchy)
  • InterPro Domains
    IPR050918 CNF-like Phospholipase A2 Inhibitor
    IPR016054 Ly-6 antigen/uPA receptor-like
    IPR004126 Phospholipase A2 inhibitor, N-terminal domain
    IPR045860 Snake toxin-like superfamily
Molecular
Reagents
less
  • All nucleic 16
    cDNA 16

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:322222 Liu Z, et al., Phospholipase A2 inhibitor and LY6/PLAUR domain-containing protein PINLYP regulates type I interferon innate immunity. Proc Natl Acad Sci U S A. 2022 Jan 4;119(1):e2111115119
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory