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Fam222a Gene Detail
Summary
  • Symbol
    Fam222a
  • Name
    family with sequence similarity 222, member A
  • Synonyms
    BC057022
  • Feature Type
    protein coding gene
  • IDs
    MGI:3605543
    NCBI Gene: 433940
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:114706312-114751281 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 55.99 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1231 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3605543
 protein coding gene Chr5:114706077-114751281 (+)
129S1/SvImJ ENSMUSG00200021125
 protein coding gene Chr5:108446827-108492719 (+)
A/J ENSMUSG00195033928
 protein coding gene Chr5:107960096-108005327 (+)
AKR/J ENSMUSG00220050945
 protein coding gene Chr5:107476159-107522043 (+)
BALB/cJ ENSMUSG00180045619
 protein coding gene Chr5:108097477-108143370 (+)
C3H/HeJ ENSMUSG00175043130
 protein coding gene Chr5:110086067-110131520 (+)
C57BL/6NJ ENSMUSG00215030806
 protein coding gene Chr5:108106641-108151881 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027598
 protein coding gene Chr5:107529733-107577178 (+)
CAST/EiJ ENSTCUG00005022613
 protein coding gene Chr5:107287810-107333070 (+)
CBA/J ENSMUSG00210035966
 protein coding gene Chr5:108838139-108883587 (+)
DBA/2J ENSMUSG00185044267
 protein coding gene Chr5:111889159-111934586 (+)
FVB/NJ ENSMUSG00205051297
 protein coding gene Chr5:107736350-107781807 (+)
JF1/MsJ ENSUMUG00000023500
 protein coding gene Chr5:114731018-114776216 (+)
LP/J ENSMUSG00230048465
 protein coding gene Chr5:115985002-116030892 (+)
NOD/ShiLtJ ENSMUSG00190028307
 protein coding gene Chr5:107774650-107819875 (+)
NZO/HlLtJ ENSMUSG00225013471
 protein coding gene Chr5:123638623-123684032 (+)
PWK/PhJ ENSLUMG00010037468
 protein coding gene Chr5:106634785-106680030 (+)
SPRET/EiJ ENSMSPG00010042749
 protein coding gene Chr5:109914601-109960675 (+)
WSB/EiJ ENSIUOG00005040403
 protein coding gene Chr5:110477888-110523745 (+)



Homology
more
  • Human Ortholog
    FAM222A, family with sequence similarity 222 member A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FAM222A, family with sequence similarity 222 member A
  • Synonyms
    C12orf34
  • Links
    NCBI Gene ID: 84915
    UniProt: Q5U5X8

  • Chr Location
    12q24.11; chr12:109713825-109770495 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    601
  • Tissues
    3
  • cDNA Data
    5
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 433940 NCBI Gene Model | MGI Sequence Detail 44970 C57BL/6J ±  kb
    transcript NM_001004180 RefSeq | MGI Sequence Detail 2717 C57BL/6  
    polypeptide Q6PGH4 UniProt | EBI | MGI Sequence Detail 453 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 5
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 2
      Gene Ontology 1
      Phenotypes 12
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:361731 Tzani A, et al., FAM222A, Part of the BET-Regulated Basal Endothelial Transcriptome, Is a Novel Determinant of Endothelial Biology and Angiogenesis-Brief Report. Arterioscler Thromb Vasc Biol. 2024 Jan;44(1):143-155
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory