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Ccdc42 Gene Detail
Summary
  • Symbol
    Ccdc42
  • Name
    coiled-coil domain containing 42
  • Synonyms
    A530001H01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045254
    NCBI Gene: 276920
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:68477863-68488777 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 41.85 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    401 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3045254
 protein coding gene Chr11:68477847-68488792 (+)
129S1/SvImJ ENSMUSG00200044256
 protein coding gene Chr11:65420843-65431768 (+)
A/J ENSMUSG00195032599
 protein coding gene Chr11:65440331-65451257 (+)
AKR/J ENSMUSG00220054157
 protein coding gene Chr11:65556582-65567507 (+)
BALB/cJ ENSMUSG00180053660
 protein coding gene Chr11:65520939-65531886 (+)
C3H/HeJ ENSMUSG00175053066
 protein coding gene Chr11:65471291-65482243 (+)
C57BL/6NJ ENSMUSG00215052776
 protein coding gene Chr11:65246486-65257435 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016539
 protein coding gene Chr11:63311693-63321507 (+)
CAST/EiJ ENSTCUG00005053196
 protein coding gene Chr11:64995552-65005707 (+)
CBA/J ENSMUSG00210054232
 protein coding gene Chr11:65325396-65336348 (+)
DBA/2J ENSMUSG00185040888
 protein coding gene Chr11:65519640-65529906 (+)
FVB/NJ ENSMUSG00205050837
 protein coding gene Chr11:65415343-65426292 (+)
JF1/MsJ ENSUMUG00000049497
 protein coding gene Chr11:65917816-65928086 (+)
LP/J ENSMUSG00230053650
 protein coding gene Chr11:66631232-66642156 (+)
NOD/ShiLtJ ENSMUSG00190054049
 protein coding gene Chr11:65553028-65563970 (+)
NZO/HlLtJ ENSMUSG00225044457
 protein coding gene Chr11:68806985-68817190 (+)
PWK/PhJ ENSLUMG00010037482
 protein coding gene Chr11:65428080-65438367 (+)
SPRET/EiJ ENSMSPG00010040120
 protein coding gene Chr11:66168003-66177959 (+)
WSB/EiJ ENSIUOG00005041631
 protein coding gene Chr11:65452370-65463289 (+)



Homology
more
  • Human Ortholog
    CCDC42, coiled-coil domain containing 42
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCDC42, coiled-coil domain containing 42
  • Synonyms
    CCDC42A
  • Links
    NCBI Gene ID: 146849
    UniProt: Q96M95

  • Chr Location
    17p13.1; chr17:8729930-8745970 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and developmentally normal with no overt behavioral deficits. Males exhibit defects in the number and location of the sperm head-tail coupling apparatus, lack flagellated sperm, and are sterile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    646
  • Tissues
    49
  • cDNA Data
    13
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 276920 NCBI Gene Model | MGI Sequence Detail 10915 C57BL/6J ±  kb
    transcript NM_177779 RefSeq | MGI Sequence Detail 1353 C57BL/6  
    polypeptide Q5SV66 UniProt | EBI | MGI Sequence Detail 316 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000030312 coiled-coil domain-containing protein 42
      (term hierarchy)
    • InterPro Domains
      IPR051147 Cilia- and flagella-associated protein and CCDC
      IPR025252 Domain of unknown function DUF4200
    • GlyGen
      Q5SV66 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 1
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 8
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:344445 Ma Y, et al., CCDC146 is required for sperm flagellum biogenesis and male fertility in mice. Cell Mol Life Sci. 2023 Dec 1;81(1):1
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory