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Kcnt2 Gene Detail
Summary
  • Symbol
    Kcnt2
  • Name
    potassium channel, subfamily T, member 2
  • Synonyms
    E330038N15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3036273
    NCBI Gene: 240776
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:140173896-140539805 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 61.62 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    10090 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3036273
 protein coding gene Chr1:140173373-140541783 (+)
129S1/SvImJ ENSMUSG00200007549
 protein coding gene Chr1:137582503-137953580 (+)
A/J ENSMUSGG00195055212
 protein coding gene Chr1:137018991-137037101 (+)
AKR/J ENSMUSGG00220054777
 protein coding gene Chr1:136807151-136825245 (+)
BALB/cJ ENSMUSGG00180055125
 protein coding gene Chr1:137262547-137280648 (+)
C3H/HeJ ENSMUSGG00175054957
 protein coding gene Chr1:137234153-137252266 (+)
C57BL/6NJ ENSMUSGG00215055652
 protein coding gene Chr1:137192981-137211078 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014672
 protein coding gene Chr1:131849874-132200655 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054951
 protein coding gene Chr1:137182348-137200455 (+)
DBA/2J ENSMUSGG00185057389
 protein coding gene Chr1:141510895-141528994 (+)
FVB/NJ ENSMUSGG00205054452
 protein coding gene Chr1:136419526-136437633 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055476
 protein coding gene Chr1:141024956-141043053 (+)
NOD/ShiLtJ ENSMUSGG00190054585
 protein coding gene Chr1:136999906-137018014 (+)
NZO/HlLtJ ENSMUSG00225000064
 protein coding gene Chr1:144712506-145074734 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010011865
 protein coding gene Chr1:138857380-139220462 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    KCNT2, potassium sodium-activated channel subfamily T member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNT2, potassium sodium-activated channel subfamily T member 2
  • Synonyms
    DEE57, EIEE57, KCa4.2, KNa1.2, SLICK, SLO2.1
  • Links
    NCBI Gene ID: 343450
    UniProt: Q6UVM3

  • Chr Location
    1q31.3; chr1:196225779-196609225 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human KCNT2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are viable with normal pain and itch responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    633
  • Tissues
    23
  • cDNA Data
    2
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052726 Ensembl Gene Model | MGI Sequence Detail 365910 C57BL/6J ±  kb
    transcript ENSMUST00000120796 Ensembl | MGI Sequence Detail 3540 Not Applicable  
    polypeptide ENSMUSP00000113333 Ensembl | MGI Sequence Detail 1135 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000002081 potassium channel subfamily T member 2
      (term hierarchy)
    • InterPro Domains
      IPR003929 Calcium-activated potassium channel BK, alpha subunit
      IPR047871 Calcium-activated potassium channel slowpoke-like
      IPR036291 NAD(P)-binding domain superfamily
      IPR013099 Potassium channel domain
      IPR003148 Regulator of K+ conductance, N-terminal lobe
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 2
      Primer pair 1
      Antibodies 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 20
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:361746 Hata K, et al., Serinc5 Regulates Sequential Chondrocyte Differentiation by Inhibiting Sox9 Function in Pre-Hypertrophic Chondrocytes. J Cell Physiol. 2025 Jan;240(1):e31490
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory