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Nlrp9c Gene Detail
Summary
  • Symbol
    Nlrp9c
  • Name
    NLR family, pyrin domain containing 9C
  • Synonyms
    Nalp9c, Nalp-zeta
Location &
Maps
more
  • Sequence Map
    Chr7:26064116-26103125 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 14.44 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1036 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3028627
 protein coding gene Chr7:26021898-26103125 (-)
129S1/SvImJ ENSMUSG00200040239
 protein coding gene Chr7:15816038-15887750 (-)
A/J ENSMUSG00195048371
 protein coding gene Chr7:18469731-18540618 (-)
AKR/J ENSMUSG00220045077
 protein coding gene Chr7:25895696-25931534 (+)
BALB/cJ ENSMUSG00180048699
 protein coding gene Chr7:16535085-16605975 (-)
C3H/HeJ ENSMUSG00175039804
 protein coding gene Chr7:17578994-17650772 (-)
C57BL/6NJ ENSMUSG00215054197
 protein coding gene Chr7:15822364-15894144 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029386
 protein coding gene Chr7:25578712-25605998 (-)
CAST/EiJ ENSTCUG00005047006
 protein coding gene Chr7:17540596-17608308 (-)
CBA/J ENSMUSG00210052060
 protein coding gene Chr7:16764689-16836454 (-)
DBA/2J ENSMUSG00185053232
 protein coding gene Chr7:19978635-20050387 (-)
FVB/NJ ENSMUSG00205038015
 protein coding gene Chr7:17043637-17083377 (+)
JF1/MsJ ENSUMUG00000039675
 protein coding gene Chr7:24318602-24386974 (-)
LP/J ENSMUSG00230051642
 protein coding gene Chr7:25042070-25113784 (-)
NOD/ShiLtJ ENSMUSG00190028800
 protein coding gene Chr7:16271306-16296706 (+)
NZO/HlLtJ ENSMUSG00225023013
 protein coding gene Chr7:23920641-23992401 (-)
PWK/PhJ ENSLUMG00010036541
 protein coding gene Chr7:16242145-16313824 (-)
SPRET/EiJ ENSMSPG00010050003
 protein coding gene Chr7:15708283-15733582 (-)
WSB/EiJ ENSIUOG00005049920
 protein coding gene Chr7:6365272-6394699 (-)



Homology
more
  • Human Ortholog
    NLRP9, NLR family pyrin domain containing 9
  • Vertebrate Orthologs
    11
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NLRP9, NLR family pyrin domain containing 9
  • Synonyms
    CLR19.1, NALP9, NOD6, PAN12
  • Links
    NCBI Gene ID: 338321
    UniProt: Q7RTR0

  • Chr Location
    19q13.42; chr19:55708438-55738402 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from multigenic genotypes
    7 phenotype references
Mice homozygous for null alleles of Nlrp9a, Nlrp9b, and Nlrp9c exhibit reduced litter size, incomplete preimplantation lethality, delayed or impaired blastocyst formation, and failure of cell division at the 2 cell stage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    8
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 330490 NCBI Gene Model | MGI Sequence Detail 39010 C57BL/6J ±  kb
transcript NM_001042612 RefSeq | MGI Sequence Detail 3277 C57BL/6  
polypeptide Q66X01 UniProt | EBI | MGI Sequence Detail 1004 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000011570 NACHT, LRR and PYD domains-containing protein 9C
    (term hierarchy)
  • InterPro Domains
    IPR004020 DAPIN domain
    IPR011029 Death-like domain superfamily
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain superfamily
    IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2
    IPR007111 NACHT nucleoside triphosphatase
    IPR050637 NLRP family, innate immunity and inflammation regulators
    IPR041075 NOD1/2, winged helix domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 3
Other
Accession IDs
less
MGI:3034513, MGI:3035139
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:92340 Anderson JP, et al., Structural, expression, and evolutionary analysis of mouse CIAS1. Gene. 2004 Aug 18;338(1):25-34
  • Latest
    J:386971 Tran LM, et al., Role of P450 enzymes of the Cyp2abfgs gene subfamilies in tobacco smoke-induced lung tumorigenesis in mice. Carcinogenesis. 2026 Mar 19;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory