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Prob1 Gene Detail
Summary
  • Symbol
    Prob1
  • Name
    proline rich basic protein 1
  • Synonyms
    Gm1614, LOC381148
  • Feature Type
    protein coding gene
  • IDs
    MGI:2686460
    NCBI Gene: 381148
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:35783400-35788274 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 19.20 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    179 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2686460
 protein coding gene Chr18:35783400-35788291 (-)
129S1/SvImJ ENSMUSG00200041081
 protein coding gene Chr18:32782188-32787075 (-)
A/J ENSMUSG00195032408
 protein coding gene Chr18:32948893-32953780 (-)
AKR/J ENSMUSG00220015974
 protein coding gene Chr18:32925212-32930099 (-)
BALB/cJ ENSMUSG00180017372
 protein coding gene Chr18:33398528-33403415 (-)
C3H/HeJ ENSMUSG00175035053
 protein coding gene Chr18:32906039-32910926 (-)
C57BL/6NJ ENSMUSG00215016046
 protein coding gene Chr18:32652279-32657166 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022112
 protein coding gene Chr18:32907957-32912855 (-)
CAST/EiJ ENSTCUG00005023431
 protein coding gene Chr18:32558434-32563318 (-)
CBA/J ENSMUSG00210020077
 protein coding gene Chr18:32940685-32945572 (-)
DBA/2J ENSMUSG00185018968
 protein coding gene Chr18:32875247-32880134 (-)
FVB/NJ ENSMUSG00205027641
 protein coding gene Chr18:32587070-32591957 (-)
JF1/MsJ ENSUMUG00000031430
 protein coding gene Chr18:33031532-33036416 (-)
LP/J ENSMUSG00230046155
 protein coding gene Chr18:34978978-34983865 (-)
NOD/ShiLtJ ENSMUSG00190018613
 protein coding gene Chr18:32659858-32664745 (-)
NZO/HlLtJ ENSMUSG00225044356
 protein coding gene Chr18:34883778-34888665 (-)
PWK/PhJ ENSLUMG00010011138
 protein coding gene Chr18:33184175-33189059 (-)
SPRET/EiJ ENSMSPG00010017371
 protein coding gene Chr18:33233506-33236679 (-)
WSB/EiJ ENSIUOG00005007706
 protein coding gene Chr18:32646695-32651582 (-)



Homology
more
  • Human Ortholog
    PROB1, proline rich basic protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PROB1, proline rich basic protein 1
  • Synonyms
    C5orf65
  • Links
    NCBI Gene ID: 389333
    UniProt: E7EW31

  • Chr Location
    5q31.2; chr5:139390592-139395104 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    658
  • Tissues
    9
  • cDNA Data
    9
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 381148 NCBI Gene Model | MGI Sequence Detail 4875 C57BL/6J ±  kb
    transcript NM_001270646 RefSeq | MGI Sequence Detail 4875 C57BL/6  
    polypeptide NP_001257575 RefSeq | MGI Sequence Detail 1010 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR052303 Cardiac-enriched FHL2-interacting protein-related
      IPR027838 Domain of unknown function DUF4585
    • GlyGen
      A0A087WR45 3 sites
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 3
    References
    more
    • Summaries
      All 26
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 5
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory