Naaladl2 MGI Mouse Gene Detail - MGI:2685867 - N-acetylated alpha-linked acidic dipeptidase-like 2

Symbol

Naaladl2
Name

N-acetylated alpha-linked acidic dipeptidase-like 2
Synonyms

2810043G22Rik, EG635702, LOC381500

Feature Type

protein coding gene
IDs

MGI:2685867
NCBI Gene: 635702
Alliance

genome feature page
Transcription Start Sites

12 TSS

Sequence Map

Chr3:23852267-25198425 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 9.24 cM
Mapping Data

3 experiments

SNPs within 2kb

38491 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685867	protein coding gene	Chr3:23852266-25198425 (-)
129S1/SvImJ	ENSMUSG00200023895	protein coding gene	Chr3:20572588-21558159 (-)
A/J	ENSMUSG00195021204	protein coding gene	Chr3:20707928-21693557 (-)
AKR/J	ENSMUSG00220008360	protein coding gene	Chr3:20695533-21687866 (-)
BALB/cJ	ENSMUSG00180030065	protein coding gene	Chr3:20710667-21696249 (-)
C3H/HeJ	ENSMUSG00175027218	protein coding gene	Chr3:20700914-21686464 (-)
C57BL/6NJ	ENSMUSG00215013895	protein coding gene	Chr3:20941542-21927144 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024884	protein coding gene	Chr3:19218922-20455540 (-)
CAST/EiJ	ENSTCUG00005023727	protein coding gene	Chr3:20522460-21863344 (-)
CBA/J	ENSMUSG00210034565	protein coding gene	Chr3:20680988-21666513 (-)
DBA/2J	ENSMUSG00185008484	protein coding gene	Chr3:20924203-21909784 (-)
FVB/NJ	ENSMUSG00205002486	protein coding gene	Chr3:20229559-21208786 (-)
JF1/MsJ	ENSUMUG00000016818	protein coding gene	Chr3:20458656-21436437 (-)
LP/J	ENSMUSG00230001232	protein coding gene	Chr3:22799815-23785301 (-)
NOD/ShiLtJ	ENSMUSG00190031897	protein coding gene	Chr3:21082608-21952413 (-)
NZO/HlLtJ	ENSMUSG00225006915	protein coding gene	Chr3:25445948-26431538 (-)
PWK/PhJ	ENSLUMG00010002959	protein coding gene	Chr3:20423223-21758022 (-)
SPRET/EiJ	ENSMSPG00010022165	protein coding gene	Chr3:20751896-22135225 (-)
WSB/EiJ	ENSIUOG00005032283	protein coding gene	Chr3:20920126-22294910 (-)

Human Ortholog

NAALADL2, N-acetylated alpha-linked acidic dipeptidase like 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NAALADL2, N-acetylated alpha-linked acidic dipeptidase like 2
Links

HGNC:23219

NCBI Gene ID: 254827

UniProt: Q58DX5
Chr Location

3q26.31; chr3:174438573-175810548 (+) GRCh38

MGI Vertebrate Homology

Naaladl2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: NAALADL2
Gene Tree

Naaladl2

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

3
Radiation induced

1
Genomic Mutations

1 involving Naaladl2
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

4
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

644
Tissues

9
cDNA Data

9
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

36
RefSeq

7
UniProt

1
CCDS

CCDS84612.1

Ensembl

ENSMUSG00000102758 (Evidence)
NCBI Gene

635702

			Length	Strain/Species	Flank
genomic	635702	NCBI Gene Model \| MGI Sequence Detail	1346159	C57BL/6J	± kb
transcript	NM_001326288	RefSeq \| MGI Sequence Detail	9274	C57BL/6
polypeptide	NP_001313217	RefSeq \| MGI Sequence Detail	795	C57BL/6

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UniProt

1 Sequence
InterPro Domains

IPR046450 PA domain superfamily

IPR036757 Transferrin receptor-like, dimerisation domain superfamily

IPR039373 Transferrin receptor protein 1/Glutamate carboxypeptidase 2-like
GlyGen

A0A0N4SUJ3 5 sites, 4 N-linked glycans (4 sites)

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All nucleic 9

cDNA 9

Microarray probesets 5

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MGI:1919932, MGI:3643277

Summaries

All 29

Developmental Gene Expression 1

Diseases 1

Gene Ontology 4

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Naaladl2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr32771	Chr3:25198442-25198494 (-)	-43 bp
Tssr32770	Chr3:25198413-25198434 (-)	1 bp
Tssr32769	Chr3:25198346-25198412 (-)	46 bp
Tssr32768	Chr3:25009308-25009310 (-)	189,116 bp
Tssr32767	Chr3:24912389-24912400 (-)	286,030 bp
Tssr32766	Chr3:24912361-24912373 (-)	286,058 bp
Tssr32765	Chr3:24837772-24837785 (-)	360,646 bp
Tssr32764	Chr3:24837725-24837771 (-)	360,677 bp
Tssr32763	Chr3:24814488-24814492 (-)	383,935 bp
Tssr32762	Chr3:24601276-24601280 (-)	597,147 bp
Tssr32761	Chr3:24192292-24192293 (-)	1,006,132 bp
Tssr32760	Chr3:23993616-23993629 (-)	1,204,802 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24