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Spata22 Gene Detail
Summary
  • Symbol
    Spata22
  • Name
    spermatogenesis associated 22
  • Synonyms
    LOC380709
Location &
Maps
more
  • Sequence Map
    Chr11:73220567-73236870 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 45.29 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    41 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685728
 protein coding gene Chr11:73217416-73237447 (+)
129S1/SvImJ ENSMUSG00200048048
 protein coding gene Chr11:70263364-70279664 (+)
A/J ENSMUSG00195050888
 protein coding gene Chr11:70196051-70211112 (+)
AKR/J ENSMUSG00220054135
 protein coding gene Chr11:70439434-70455733 (+)
BALB/cJ ENSMUSG00180043271
 protein coding gene Chr11:70361061-70377363 (+)
C3H/HeJ ENSMUSG00175054342
 protein coding gene Chr11:70308301-70324601 (+)
C57BL/6NJ ENSMUSG00215053248
 protein coding gene Chr11:69991313-70007616 (+)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005053143
 protein coding gene Chr11:69862284-69877277 (+)
CBA/J ENSMUSG00210050786
 protein coding gene Chr11:70162288-70178588 (+)
DBA/2J ENSMUSG00185056560
 protein coding gene Chr11:70443796-70460096 (+)
FVB/NJ ENSMUSG00205034269
 protein coding gene Chr11:70280173-70296476 (+)
JF1/MsJ ENSUMUG00000049104
 protein coding gene Chr11:70837746-70852838 (+)
LP/J ENSMUSG00230047864
 protein coding gene Chr11:71474378-71490678 (+)
NOD/ShiLtJ ENSMUSG00190054076
 protein coding gene Chr11:70435321-70451621 (+)
NZO/HlLtJ ENSMUSG00225039082
 protein coding gene Chr11:73658465-73673526 (+)
PWK/PhJ ENSLUMG00010039764
 protein coding gene Chr11:70331117-70346223 (+)
SPRET/EiJ ENSMSPG00010041402
 protein coding gene Chr11:70872323-70901034 (+)
WSB/EiJ ENSIUOG00005045076
 protein coding gene Chr11:70389264-70404316 (+)



Homology
more
  • Human Ortholog
    SPATA22, spermatogenesis associated 22
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPATA22, spermatogenesis associated 22
  • Synonyms
    NYD-SP20, NYDSP20, POF25, SPGF96
  • Links
    NCBI Gene ID: 84690
    UniProt: Q8NHS9

  • Chr Location
    17p13.2; chr17:3440019-3513858 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 4 alleles in 6 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutations of this gene result in small gonads, severe germ cell depletion, and sterility in both males and females due to meiotic prophase I arrest associated with abnormal synaptonemal complex formation, chromosome asynapsis, and impaired double strand break repair.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    619
  • Tissues
    6
  • cDNA Data
    3
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000112920 Ensembl Gene Model | MGI Sequence Detail 16304 C57BL/6J ±  kb
    transcript ENSMUST00000092926 Ensembl | MGI Sequence Detail 1274 Not Applicable  
    polypeptide ENSMUSP00000090602 Ensembl | MGI Sequence Detail 358 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 3
      Primer pair 2
      Antibodies 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 10
      Gene Ontology 12
      Phenotypes 19
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:378362 Ruan T, et al., A novel dual histone mark reader ZCWPW2 regulates meiotic recombination through lactylation and transcriptional regulation in humans and mice. Nucleic Acids Res. 2026 Jan 22;54(3)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory