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Tmem196 Gene Detail
Summary
  • Symbol
    Tmem196
  • Name
    transmembrane protein 196
  • Synonyms
    LOC217951
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685374
    NCBI Gene: 217951
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:119909557-119984981 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 63.86 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    994 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685374
 protein coding gene Chr12:119909422-119984981 (+)
129S1/SvImJ ENSMUSG00200026447
 protein coding gene Chr12:112287014-112361296 (+)
A/J ENSMUSG00195010272
 protein coding gene Chr12:114979430-115060668 (+)
AKR/J ENSMUSG00220031710
 protein coding gene Chr12:112088168-112162446 (+)
BALB/cJ ENSMUSG00180006370
 protein coding gene Chr12:114784519-114860155 (+)
C3H/HeJ ENSMUSG00175002195
 protein coding gene Chr12:115855893-115930175 (+)
C57BL/6NJ ENSMUSG00215004782
 protein coding gene Chr12:112781666-112857276 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018190
 protein coding gene Chr12:114654675-114722794 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210012279
 protein coding gene Chr12:113138475-113212752 (+)
DBA/2J ENSMUSG00185014224
 protein coding gene Chr12:115636552-115710825 (+)
FVB/NJ ENSMUSG00205005141
 protein coding gene Chr12:114140278-114215904 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230042061
 protein coding gene Chr12:122006118-122081720 (+)
NOD/ShiLtJ ENSMUSG00190024173
 protein coding gene Chr12:111655803-111730062 (+)
NZO/HlLtJ ENSMUSG00225041721
 protein coding gene Chr12:123846834-123928090 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    TMEM196, transmembrane protein 196
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM196, transmembrane protein 196
  • Links
    NCBI Gene ID: 256130
    UniProt: Q5HYL7

  • Chr Location
    7p21.1; chr7:19719315-19773617 (-)  GRCh38
Human Diseases
less
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    63 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    604
  • Tissues
    5
  • cDNA Data
    4
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048004 Ensembl Gene Model | MGI Sequence Detail 75425 C57BL/6J ±  kb
transcript ENSMUST00000183694 Ensembl | MGI Sequence Detail 845 Not Applicable  
polypeptide ENSMUSP00000138921 Ensembl | MGI Sequence Detail 182 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 2
References
more
  • Summaries
    All 83
    Developmental Gene Expression 1
    Diseases 4
    Gene Ontology 4
    Phenotypes 63
  • Earliest
    J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
  • Latest
    J:385727 Harada K, et al., Preventing Differentiation Towards Primitive Macrophages in Stem Cells With Down Syndrome. Immunology. 2026 Mar;177(3):596-612
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory