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Nxf3 Gene Detail
Summary
  • Symbol
    Nxf3
  • Name
    nuclear RNA export factor 3
  • Synonyms
    LOC245610
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685230
    NCBI Gene: 245610
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:134972848-134986004 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 57.38 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    362 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685230
 protein coding gene ChrX:134972272-135040382 (-)
129S1/SvImJ ENSMUSG00200045970
 protein coding gene ChrX:114047303-114060449 (-)
A/J ENSMUSG00195044432
 protein coding gene ChrX:117832238-117845394 (-)
AKR/J ENSMUSG00220034594
 protein coding gene ChrX:111280836-111293981 (-)
BALB/cJ ENSMUSG00180033040
 protein coding gene ChrX:114265429-114278587 (-)
C3H/HeJ ENSMUSG00175030198
 protein coding gene ChrX:118200877-118214025 (-)
C57BL/6NJ ENSMUSG00215043487
 protein coding gene ChrX:114675205-114688359 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033415
 protein coding gene ChrX:124829621-124841977 (-)
CAST/EiJ ENSTCUG00005036540
 protein coding gene ChrX:115356315-115369237 (-)
CBA/J ENSMUSG00210040169
 protein coding gene ChrX:115136560-115149704 (-)
DBA/2J ENSMUSG00185029162
 protein coding gene ChrX:129027426-129040574 (-)
FVB/NJ ENSMUSG00205029615
 protein coding gene ChrX:113483123-113496282 (-)
JF1/MsJ ENSUMUG00000020705
 protein coding gene ChrX:148157557-148170660 (-)
LP/J ENSMUSG00230036014
 protein coding gene ChrX:135655992-135669138 (-)
NOD/ShiLtJ ENSMUSG00190032074
 protein coding gene ChrX:114525825-114538963 (-)
NZO/HlLtJ ENSMUSG00225036511
 protein coding gene ChrX:140260143-140273291 (-)
PWK/PhJ ENSLUMG00010041525
 protein coding gene ChrX:112920137-112933232 (-)
SPRET/EiJ ENSMSPG00010036199
 protein coding gene ChrX:117528481-117541599 (-)
WSB/EiJ ENSIUOG00005036075
 protein coding gene ChrX:115058673-115071812 (-)



Homology
more
  • Human Ortholog
    NXF3, nuclear RNA export factor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NXF3, nuclear RNA export factor 3
  • Links
    NCBI Gene ID: 56000
    UniProt: Q9H4D5

  • Chr Location
    Xq22.1; chrX:103075810-103093143 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from multigenic genotypes
    6 phenotype references
Mice homozygous for a knock-out allele exhibit normal fertility and male reproductive system morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    606
  • Tissues
    9
  • cDNA Data
    6
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000057000 Ensembl Gene Model | MGI Sequence Detail 13157 C57BL/6J ±  kb
transcript ENSMUST00000080929 Ensembl | MGI Sequence Detail 2978 Not Applicable  
polypeptide ENSMUSP00000079730 Ensembl | MGI Sequence Detail 553 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR032710 NTF2-like domain superfamily
    IPR030217 Nuclear RNA export factor
    IPR015245 Nuclear RNA export factor Tap, RNA-binding domain
    IPR002075 Nuclear transport factor 2 domain
    IPR018222 Nuclear transport factor 2, eukaryote
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR057125 NXF1/2/3/5-like, leucine-rich repeat domain
    IPR035979 RNA-binding domain superfamily
    IPR005637 TAP C-terminal (TAP-C) domain
    IPR009060 UBA-like superfamily
Molecular
Reagents
less
  • All nucleic 7
    cDNA 6
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 26
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:97549 Sasaki M, et al., Molecular cloning and functional characterization of mouse Nxf family gene products. Genomics. 2005 May;85(5):641-53
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory