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Jcad Gene Detail
Summary
  • Symbol
    Jcad
  • Name
    junctional cadherin 5 associated
  • Synonyms
    1110056P05Rik, 9430020K01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685174
    NCBI Gene: 240185
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:4634878-4682869 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 3.01 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1060 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685174
 protein coding gene Chr18:4590775-4682869 (+)
129S1/SvImJ ENSMUSG00200022819
 protein coding gene Chr18:1506501-1599333 (+)
A/J ENSMUSG00195007967
 protein coding gene Chr18:1701552-1794396 (+)
AKR/J ENSMUSG00220018567
 protein coding gene Chr18:1688922-1787672 (+)
BALB/cJ ENSMUSG00180005304
 protein coding gene Chr18:2163909-2256745 (+)
C3H/HeJ ENSMUSG00175007267
 protein coding gene Chr18:1699469-1792316 (+)
C57BL/6NJ ENSMUSG00215012935
 protein coding gene Chr18:1422433-1515264 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021970
 protein coding gene Chr18:1302247-1344672 (+)
CAST/EiJ ENSTCUG00005016684
 protein coding gene Chr18:1701219-1743014 (+)
CBA/J ENSMUSG00210021360
 protein coding gene Chr18:1706337-1799167 (+)
DBA/2J ENSMUSG00185029593
 protein coding gene Chr18:1695122-1794203 (+)
FVB/NJ ENSMUSG00205020861
 protein coding gene Chr18:1456862-1549700 (+)
JF1/MsJ ENSUMUG00000023269
 protein coding gene Chr18:1757924-1800051 (+)
LP/J ENSMUSG00230025318
 protein coding gene Chr18:3755888-3848708 (+)
NOD/ShiLtJ ENSMUSG00190009433
 protein coding gene Chr18:1464016-1556832 (+)
NZO/HlLtJ ENSMUSG00225033472
 protein coding gene Chr18:3684645-3777471 (+)
PWK/PhJ ENSLUMG00010009421
 protein coding gene Chr18:1924112-1966075 (+)
SPRET/EiJ ENSMSPG00010011472
 protein coding gene Chr18:1394756-1481531 (+)
WSB/EiJ ENSIUOG00005025007
 protein coding gene Chr18:1621762-1714409 (+)



Homology
more
  • Human Ortholog
    JCAD, junctional cadherin 5 associated
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    JCAD, junctional cadherin 5 associated
  • Synonyms
    KIAA1462
  • Links
    NCBI Gene ID: 57608
    UniProt: Q9P266

  • Chr Location
    10p11.23; chr10:30012803-30115494 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show decreased body weight and impaired tumor growth and tumor angiogenesis with no apparent defects in physiological vascular development and permeability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    7
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    693
  • Tissues
    7
  • cDNA Data
    41
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033960 Ensembl Gene Model | MGI Sequence Detail 47992 C57BL/6J ±  kb
    transcript ENSMUST00000037029 Ensembl | MGI Sequence Detail 6782 Not Applicable  
    polypeptide ENSMUSP00000038613 Ensembl | MGI Sequence Detail 1320 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000060126 junctional cadherin 5-associated protein
      (term hierarchy)
    • InterPro Domains
      IPR028221 Junctional cadherin 5-associated protein
    • GlyGen
      Q5DTX6 5 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 41

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1916054, MGI:5897432
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory