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Cfap119 Gene Detail
Summary
  • Symbol
    Cfap119
  • Name
    cilia and flagella associated protein 119
  • Synonyms
    Ccdc189, Gm166, LOC233899
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685012
    NCBI Gene: 233899
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127182527-127187819 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.61 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    182 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685012
 protein coding gene Chr7:127181555-127187819 (-)
129S1/SvImJ ENSMUSG00200021895
 protein coding gene Chr7:113694529-113700741 (-)
A/J ENSMUSG00195044864
 protein coding gene Chr7:118208972-118215189 (-)
AKR/J ENSMUSG00220019184
 protein coding gene Chr7:111643637-111649850 (-)
BALB/cJ ENSMUSG00180011086
 protein coding gene Chr7:114884472-114890685 (-)
C3H/HeJ ENSMUSG00175015758
 protein coding gene Chr7:115611384-115617595 (-)
C57BL/6NJ ENSMUSG00215031845
 protein coding gene Chr7:114891261-114897473 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030511
 protein coding gene Chr7:129623036-129629430 (-)
CAST/EiJ ENSTCUG00005048376
 protein coding gene Chr7:118134586-118140798 (-)
CBA/J ENSMUSG00210022654
 protein coding gene Chr7:115372325-115378537 (-)
DBA/2J ENSMUSG00185040661
 protein coding gene Chr7:119685140-119691352 (-)
FVB/NJ ENSMUSG00205032080
 protein coding gene Chr7:115328111-115334323 (-)
JF1/MsJ ENSUMUG00000039135
 protein coding gene Chr7:124748753-124755009 (-)
LP/J ENSMUSG00230051875
 protein coding gene Chr7:125794469-125800681 (-)
NOD/ShiLtJ ENSMUSG00190016532
 protein coding gene Chr7:115531052-115537269 (-)
NZO/HlLtJ ENSMUSG00225010918
 protein coding gene Chr7:124024665-124030878 (-)
PWK/PhJ ENSLUMG00010030486
 protein coding gene Chr7:113886301-113892550 (-)
SPRET/EiJ ENSMSPG00010012575
 protein coding gene Chr7:115149227-115155457 (-)
WSB/EiJ ENSIUOG00005031452
 protein coding gene Chr7:116231855-116238072 (-)



Homology
more
  • Human Ortholog
    CFAP119, cilia and flagella associated protein 119
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CFAP119, cilia and flagella associated protein 119
  • Synonyms
    C16orf93, CCDC189
  • Links
    NCBI Gene ID: 90835
    UniProt: A1A4V9

  • Chr Location
    16p11.2; chr16:30757423-30762221 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 3 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility, decreased testis size and weight, oligozoospermia, asthenozoospermia, and teratozoospermia with abnormal sperm head morphology and multiple morphological abnormalities of the sperm flagella.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    727
  • Tissues
    16
  • cDNA Data
    18
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 233899 NCBI Gene Model | MGI Sequence Detail 5293 C57BL/6J ±  kb
    transcript NR_175799 RefSeq | MGI Sequence Detail 1158 C57BL/6  
    polypeptide Q6NZQ0 UniProt | EBI | MGI Sequence Detail 333 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:7413980
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory