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Cpap Gene Detail
Summary
  • Symbol
    Cpap
  • Name
    centrosome assembly and centriole elongation protein
  • Synonyms
    4932437H03Rik, Cenpj, Sas4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684927
    NCBI Gene: 219103
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:56764218-56812882 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 28.28 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1002 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684927
 protein coding gene Chr14:56764218-56812950 (-)
129S1/SvImJ ENSMUSG00200041420
 protein coding gene Chr14:45349011-45397639 (-)
A/J ENSMUSG00195030171
 protein coding gene Chr14:45564222-45612856 (-)
AKR/J ENSMUSG00220026658
 protein coding gene Chr14:44891019-44939653 (-)
BALB/cJ ENSMUSG00180051268
 protein coding gene Chr14:45186267-45234897 (-)
C3H/HeJ ENSMUSG00175048507
 protein coding gene Chr14:46875028-46923644 (-)
C57BL/6NJ ENSMUSG00215048378
 protein coding gene Chr14:45083125-45131751 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019338
 protein coding gene Chr14:47771026-47812035 (-)
CAST/EiJ ENSTCUG00005046689
 protein coding gene Chr14:46855332-46903976 (-)
CBA/J ENSMUSG00210041732
 protein coding gene Chr14:45554715-45603346 (-)
DBA/2J ENSMUSG00185053303
 protein coding gene Chr14:50671051-50719920 (-)
FVB/NJ ENSMUSG00205037972
 protein coding gene Chr14:44958288-45006949 (-)
JF1/MsJ ENSUMUG00000038863
 protein coding gene Chr14:61835542-61880804 (-)
LP/J ENSMUSG00230052642
 protein coding gene Chr14:62718098-62766719 (-)
NOD/ShiLtJ ENSMUSG00190040706
 protein coding gene Chr14:45321048-45369671 (-)
NZO/HlLtJ ENSMUSG00225046074
 protein coding gene Chr14:53008444-53057063 (-)
PWK/PhJ ENSLUMG00010039908
 protein coding gene Chr14:44778201-44826821 (-)
SPRET/EiJ ENSMSPG00010040932
 protein coding gene Chr14:48281705-48324482 (-)
WSB/EiJ ENSIUOG00005042194
 protein coding gene Chr14:44738852-44785268 (-)



Homology
more
  • Human Ortholog
    CPAP, centrosome assembly and centriole elongation protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CPAP, centrosome assembly and centriole elongation protein
  • Synonyms
    BM032, CENP-J, CENPJ, LAP, LIP1, MCPH6, Sas-4, SASS4, SCKL4
  • Links
    NCBI Gene ID: 55835
    UniProt: Q9HC77

  • Chr Location
    13q12.12-q12.13; chr13:24882276-24934000 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cpap mouse models; 3 with human CPAP associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    82 phenotypes from 5 alleles in 5 genetic backgrounds
    7 phenotypes from multigenic genotypes
    3 images
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null alleles exhibit embryonic lethality during early organogenesis and may show failure of embryo turning and absence of centrioles, cilia and centrosomes. Mice homozygous for a hypomorphic allele display partial lethality, dwarfism and a wide range of abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    68
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    767
  • Tissues
    26
  • cDNA Data
    43
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000064128 Ensembl Gene Model | MGI Sequence Detail 48665 C57BL/6J ±  kb
    transcript ENSMUST00000225951 Ensembl | MGI Sequence Detail 4756 Not Applicable  
    polypeptide ENSMUSP00000153013 Ensembl | MGI Sequence Detail 1344 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      cDNA 43
      Primer pair 1
      Antibodies 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:7783601
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 12
      Phenotypes 27
    • Earliest
      J:78713 Peng B, et al., CPAP Is a Novel Stat5-Interacting Cofactor that Augments Stat5-Mediated Transcriptional Activity. Mol Endocrinol. 2002 Sep;16(9):2019-33
    • Latest
      J:367690 Skinner MW, et al., Meiotic divisions and round spermatid formation do not require centriole duplication in mice. PLoS Genet. 2025 Apr;21(4):e1011698
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory