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Sh3tc1 Gene Detail
Summary
  • Symbol
    Sh3tc1
  • Name
    SH3 domain and tetratricopeptide repeats 1
  • Synonyms
    MGC:67153
  • Feature Type
    protein coding gene
  • IDs
    MGI:2678949
    NCBI Gene: 231147
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:35854524-35897331 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 18.60 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1348 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2678949
 protein coding gene Chr5:35854524-35897331 (-)
129S1/SvImJ ENSMUSG00200031924
 protein coding gene Chr5:31323882-31350846 (-)
A/J ENSMUSG00195027853
 protein coding gene Chr5:30797899-30824859 (-)
AKR/J ENSMUSG00220002021
 protein coding gene Chr5:30824686-30851650 (-)
BALB/cJ ENSMUSG00180031916
 protein coding gene Chr5:30600769-30627731 (-)
C3H/HeJ ENSMUSG00175019635
 protein coding gene Chr5:32580290-32607250 (-)
C57BL/6NJ ENSMUSG00215005247
 protein coding gene Chr5:31321125-31348089 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027151
 protein coding gene Chr5:30641179-30685607 (-)
CAST/EiJ ENSTCUG00005023566
 protein coding gene Chr5:30802583-30831012 (-)
CBA/J ENSMUSG00210003856
 protein coding gene Chr5:31549109-31576067 (-)
DBA/2J ENSMUSG00185016426
 protein coding gene Chr5:33416231-33443995 (-)
FVB/NJ ENSMUSG00205040619
 protein coding gene Chr5:30296560-30324322 (-)
JF1/MsJ ENSUMUG00000039592
 protein coding gene Chr5:38014441-38041496 (-)
LP/J ENSMUSG00230041515
 protein coding gene Chr5:38027499-38054464 (-)
NOD/ShiLtJ ENSMUSG00190002738
 protein coding gene Chr5:30578648-30606410 (-)
NZO/HlLtJ ENSMUSG00225015304
 protein coding gene Chr5:43230859-43257808 (-)
PWK/PhJ ENSLUMG00010022233
 protein coding gene Chr5:30708445-30735460 (-)
SPRET/EiJ ENSMSPG00010034051
 protein coding gene Chr5:31922276-31965624 (-)
WSB/EiJ ENSIUOG00005017190
 protein coding gene Chr5:33505417-33533182 (-)



Homology
more
  • Human Ortholog
    SH3TC1, SH3 domain and tetratricopeptide repeats 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SH3TC1, SH3 domain and tetratricopeptide repeats 1
  • Links
    NCBI Gene ID: 54436
    UniProt: Q8TE82

  • Chr Location
    4p16.1; chr4:8182072-8241803 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    700
  • Tissues
    6
  • cDNA Data
    36
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 231147 NCBI Gene Model | MGI Sequence Detail 42808 C57BL/6J ±  kb
    transcript NM_194344 RefSeq | MGI Sequence Detail 4549 C57BL/6  
    polypeptide NP_919325 RefSeq | MGI Sequence Detail 1346 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • InterPro Domains
      IPR001452 SH3 domain
      IPR042772 SH3 domain and tetratricopeptide repeat-containing protein SH3TC1/SH3TC2
      IPR036028 SH3-like domain superfamily
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
    • GlyGen
      G3X9F6 1 site
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 36

      Microarray probesets 2
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 1
      Diseases 1
      Phenotypes 30
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory