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Thoc6 Gene Detail
Summary
  • Symbol
    Thoc6
  • Name
    THO complex 6
  • Synonyms
    F830014G06Rik, Wdr58
  • Feature Type
    protein coding gene
  • IDs
    MGI:2677480
    NCBI Gene: 386612
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:23887588-23892856 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 11.97 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    133 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2677480
 protein coding gene Chr17:23887588-23892891 (-)
129S1/SvImJ ENSMUSG00200037478
 protein coding gene Chr17:19312060-19317878 (-)
A/J ENSMUSG00195035432
 protein coding gene Chr17:20330253-20336073 (-)
AKR/J ENSMUSG00220021924
 protein coding gene Chr17:19385504-19391289 (-)
BALB/cJ ENSMUSG00180014440
 protein coding gene Chr17:19612867-19618687 (-)
C3H/HeJ ENSMUSG00175033535
 protein coding gene Chr17:19398607-19404394 (-)
C57BL/6NJ ENSMUSG00215039707
 protein coding gene Chr17:19395223-19401006 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021150
 protein coding gene Chr17:19503519-19508546 (-)
CAST/EiJ ENSTCUG00005021988
 protein coding gene Chr17:19977535-19983313 (-)
CBA/J ENSMUSG00210033289
 protein coding gene Chr17:19237468-19243255 (-)
DBA/2J ENSMUSG00185050858
 protein coding gene Chr17:21419068-21424888 (-)
FVB/NJ ENSMUSG00205017078
 protein coding gene Chr17:19688588-19694373 (-)
JF1/MsJ ENSUMUG00000053002
 protein coding gene Chr17:20893544-20899354 (-)
LP/J ENSMUSG00230054690
 protein coding gene Chr17:22816976-22822794 (-)
NOD/ShiLtJ ENSMUSG00190023118
 protein coding gene Chr17:19316919-19323158 (-)
NZO/HlLtJ ENSMUSG00225049700
 protein coding gene Chr17:24740039-24745859 (-)
PWK/PhJ ENSLUMG00010019292
 protein coding gene Chr17:18789047-18794848 (-)
SPRET/EiJ ENSMSPG00010032102
 protein coding gene Chr17:20142126-20149490 (-)
WSB/EiJ ENSIUOG00005034038
 protein coding gene Chr17:20065980-20071764 (-)



Homology
more
  • Human Ortholog
    THOC6, THO complex subunit 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    THOC6, THO complex subunit 6
  • Synonyms
    fSAP35, MMRFCGU, WDR58
  • Links
    NCBI Gene ID: 79228
    UniProt: Q86W42

  • Chr Location
    16p13.3; chr16:3022541-3027755 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with biallelic loss of function are embryonic lethal by E11.5. Embryos are smaller, show developmental delay by E9.5, and show thinner epithelium in the telencephalic vesicles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    618
  • Tissues
    7
  • cDNA Data
    46
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041319 Ensembl Gene Model | MGI Sequence Detail 5269 C57BL/6J ±  kb
    transcript ENSMUST00000047436 Ensembl | MGI Sequence Detail 1504 Not Applicable  
    polypeptide ENSMUSP00000038137 Ensembl | MGI Sequence Detail 341 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 46
      Primer pair 1
      Antibodies 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory