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Slc24a5 Gene Detail
Summary
  • Symbol
    Slc24a5
  • Name
    solute carrier family 24, member 5
  • Synonyms
    F630045L20Rik, NCKX5, NCX5, Oca6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2677271
    NCBI Gene: 317750
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:124910076-124930316 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 61.14 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    612 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2677271
 protein coding gene Chr2:124910044-124930597 (+)
129S1/SvImJ ENSMUSG00200044523
 protein coding gene Chr2:121956304-121976864 (+)
A/J ENSMUSG00195030156
 protein coding gene Chr2:121986938-122007491 (+)
AKR/J ENSMUSG00220042345
 protein coding gene Chr2:121745383-121765946 (+)
BALB/cJ ENSMUSG00180046543
 protein coding gene Chr2:121773976-121794529 (+)
C3H/HeJ ENSMUSG00175044127
 protein coding gene Chr2:122268934-122290355 (+)
C57BL/6NJ ENSMUSG00215025596
 protein coding gene Chr2:121830551-121851105 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024221
 protein coding gene Chr2:117804046-117824483 (+)
CAST/EiJ ENSTCUG00005015397
 protein coding gene Chr2:121120762-121141274 (+)
CBA/J ENSMUSG00210028306
 protein coding gene Chr2:122117472-122138891 (+)
DBA/2J ENSMUSG00185043911
 protein coding gene Chr2:121771024-121791577 (+)
FVB/NJ ENSMUSG00205027518
 protein coding gene Chr2:120982905-121003465 (+)
JF1/MsJ ENSUMUG00000010719
 protein coding gene Chr2:121623366-121644793 (+)
LP/J ENSMUSG00230033928
 protein coding gene Chr2:123594819-123615378 (+)
NOD/ShiLtJ ENSMUSG00190014921
 protein coding gene Chr2:121949928-121970492 (+)
NZO/HlLtJ ENSMUSG00225001939
 protein coding gene Chr2:131500944-131521504 (+)
PWK/PhJ ENSLUMG00010047671
 protein coding gene Chr2:121540284-121561732 (+)
SPRET/EiJ ENSMSPG00010031473
 protein coding gene Chr2:123976227-123996937 (+)
WSB/EiJ ENSIUOG00005020985
 protein coding gene Chr2:121766581-121787150 (+)



Homology
more
  • Human Ortholog
    SLC24A5, solute carrier family 24 member 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC24A5, solute carrier family 24 member 5
  • Synonyms
    JSX, NCKX5, OCA6, SHEP4
  • Links
    NCBI Gene ID: 283652
    UniProt: Q71RS6

  • Chr Location
    15q21.1; chr15:48120990-48142672 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Slc24a5 mouse models; 1 with human SLC24A5 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit hypopigmentation and ocular albinism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    17
  • cDNA Data
    20
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 317750 NCBI Gene Model | MGI Sequence Detail 20241 C57BL/6J ±  kb
    transcript NM_175034 RefSeq | MGI Sequence Detail 1641 C57BL/6  
    polypeptide Q8C261 UniProt | EBI | MGI Sequence Detail 501 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 24
      Primer pair 2

      Microarray probesets 1
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 11
      Phenotypes 10
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory