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Gramd4 Gene Detail
Summary
  • Symbol
    Gramd4
  • Name
    GRAM domain containing 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2676308
    NCBI Gene: 223752
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:85941896-86021835 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 40.48 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2338 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676308
 protein coding gene Chr15:85941896-86021837 (+)
129S1/SvImJ ENSMUSG00200035394
 protein coding gene Chr15:83070037-83150324 (+)
A/J ENSMUSG00195019253
 protein coding gene Chr15:82996842-83077367 (+)
AKR/J ENSMUSG00220028572
 protein coding gene Chr15:83050090-83130623 (+)
BALB/cJ ENSMUSG00180014536
 protein coding gene Chr15:82873280-82953571 (+)
C3H/HeJ ENSMUSG00175027477
 protein coding gene Chr15:83184408-83264936 (+)
C57BL/6NJ ENSMUSG00215018342
 protein coding gene Chr15:82961416-83041352 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020136
 protein coding gene Chr15:80048858-80127773 (+)
CAST/EiJ ENSTCUG00005030135
 protein coding gene Chr15:82464471-82544762 (+)
CBA/J ENSMUSG00210013045
 protein coding gene Chr15:82959299-83039827 (+)
DBA/2J ENSMUSG00185021804
 protein coding gene Chr15:82986248-83065634 (+)
FVB/NJ ENSMUSG00205032691
 protein coding gene Chr15:82745509-82826042 (+)
JF1/MsJ ENSUMUG00000027986
 protein coding gene Chr15:82502105-82583480 (+)
LP/J ENSMUSG00230039890
 protein coding gene Chr15:86310175-86390455 (+)
NOD/ShiLtJ ENSMUSG00190022455
 protein coding gene Chr15:82982772-83063307 (+)
NZO/HlLtJ ENSMUSG00225047171
 protein coding gene Chr15:86648128-86728514 (+)
PWK/PhJ ENSLUMG00010030599
 protein coding gene Chr15:82709037-82790357 (+)
SPRET/EiJ ENSMSPG00010012079
 protein coding gene Chr15:84368468-84447859 (+)
WSB/EiJ ENSIUOG00005010929
 protein coding gene Chr15:83050035-83130134 (+)



Homology
more
  • Human Ortholog
    GRAMD4, GRAM domain containing 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRAMD4, GRAM domain containing 4
  • Synonyms
    DIP
  • Links
    NCBI Gene ID: 23151
    UniProt: Q6IC98

  • Chr Location
    22q13.31; chr22:46575644-46682756 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    2
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    3 involving Gramd4
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    33 strains or lines available
Homozygous expression of a splicing variant leads to altered splicing, which affects dendritic cell (DC) development in the bone marrow (BM).
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    669
  • Tissues
    17
  • cDNA Data
    86
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035900 Ensembl Gene Model | MGI Sequence Detail 79940 C57BL/6J ±  kb
transcript ENSMUST00000088931 Ensembl | MGI Sequence Detail 4115 Not Applicable  
polypeptide ENSMUSP00000086321 Ensembl | MGI Sequence Detail 633 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 88
    cDNA 87
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 62
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 8
    Phenotypes 30
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory