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Rtl6 Gene Detail
Summary
  • Symbol
    Rtl6
  • Name
    retrotransposon Gag like 6
  • Synonyms
    Ldoc1l, Mar6, Mart6, MGC:73499
  • Feature Type
    protein coding gene
  • IDs
    MGI:2675858
    NCBI Gene: 223732
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:84437599-84442024 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 39.88 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    175 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2675858
 protein coding gene Chr15:84437599-84442024 (-)
129S1/SvImJ ENSMUSG00200033420
 protein coding gene Chr15:81565803-81570224 (-)
A/J ENSMUSG00195018814
 protein coding gene Chr15:81490964-81495384 (-)
AKR/J ENSMUSG00220027185
 protein coding gene Chr15:81539251-81543672 (-)
BALB/cJ ENSMUSG00180014729
 protein coding gene Chr15:81367735-81372155 (-)
C3H/HeJ ENSMUSG00175027069
 protein coding gene Chr15:81678637-81683057 (-)
C57BL/6NJ ENSMUSG00215022643
 protein coding gene Chr15:81456013-81460438 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020114
 protein coding gene Chr15:78551678-78556079 (-)
CAST/EiJ ENSTCUG00005046459
 protein coding gene Chr15:80959932-80964353 (-)
CBA/J ENSMUSG00210013123
 protein coding gene Chr15:81453580-81458000 (-)
DBA/2J ENSMUSG00185022024
 protein coding gene Chr15:81490668-81495088 (-)
FVB/NJ ENSMUSG00205021760
 protein coding gene Chr15:81235924-81240345 (-)
JF1/MsJ ENSUMUG00000046515
 protein coding gene Chr15:81018018-81022415 (-)
LP/J ENSMUSG00230043048
 protein coding gene Chr15:84806060-84810481 (-)
NOD/ShiLtJ ENSMUSG00190021151
 protein coding gene Chr15:81470729-81475149 (-)
NZO/HlLtJ ENSMUSG00225050049
 protein coding gene Chr15:85137641-85142061 (-)
PWK/PhJ ENSLUMG00010051303
 protein coding gene Chr15:81227019-81231409 (-)
SPRET/EiJ ENSMSPG00010013305
 protein coding gene Chr15:82872855-82874854 (-)
WSB/EiJ ENSIUOG00005048964
 protein coding gene Chr15:81554650-81559071 (-)



Homology
more
  • Human Ortholog
    RTL6, retrotransposon Gag like 6
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RTL6, retrotransposon Gag like 6
  • Synonyms
    dJ1033E15.2, LDOC1L, Mar6, Mart6, SIRH3
  • Links
    NCBI Gene ID: 84247
    UniProt: Q6ICC9

  • Chr Location
    22q13.31; chr22:44492583-44498233 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from multigenic genotypes
    27 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Rtl6
  • Find Mice (IMSR)
    9 strains or lines available
Mice homozygous for a null allele exhibit impaired LPS removal.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    832
  • Tissues
    63
  • cDNA Data
    83
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 223732 NCBI Gene Model | MGI Sequence Detail 4426 C57BL/6J ±  kb
transcript NM_177630 RefSeq | MGI Sequence Detail 4426 C57BL/6  
polypeptide Q505G4 UniProt | EBI | MGI Sequence Detail 243 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 86
    Genomic 1
    cDNA 83
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:5906152
References
more
  • Summaries
    All 50
    Developmental Gene Expression 4
    Diseases 1
    Phenotypes 27
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory