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Gene Expression Data
Assay Details
Assay
Reference: J:83431 Morgan EA, et al., Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia. Development. 2003 Jul;130(14):3095-109
Assay type: Immunohistochemistry
MGI Accession ID: MGI:2675828
Gene symbol: Ar
Gene name: androgen receptor
Antibody: anti-AR
Detection system: Secondary antibody
Results
Specimen 9A: embryonic day 15.5; Hoxa13tm1.1Mrc/Hoxa13+ (more )
Note: Double labeled: red - Ar; green - Hoxa13 reporter (assay MGI:2681891).
Structure Level Pattern Image Note
TS23: genital tubercle of male Present Regionally restricted 9A Expression was detected in the condensing mesenchyme proximal and lateral to the urethral plate epithelium.
TS23: urethra of male Present Regionally restricted 9A Expression was detected in the surface ectoderm of the distal urethra.
Specimen 9B: embryonic day 15.5; Hoxa13tm1.1Mrc/Hoxa13tm1.1Mrc (more )
Note: Double labeled: red - Ar; green - Hoxa13 reporter (assay MGI:2681891).
Structure Level Pattern Image Note
TS23: genital tubercle of male Present Regionally restricted 9B Expression in the condensing mesenchyme proximal and lateral to the urethral plate epithelium was reduced compared to wild type.
TS23: urethra of male Present Regionally restricted 9B Expression in the surface ectoderm of the distal urethra was reduced compared to wild type.
Specimen 9C: embryonic day 15.5; Hoxa13tm1.1Mrc/Hoxa13+ (more )
Note: Double labeled: red - Ar; green - Hoxa13 reporter (assay MGI:2681891).
Structure Level Pattern Image Note
TS23: genital tubercle of male Present Regionally restricted 9C Expression was present in the mesenchyme adjacent to the urethral epithelium.
TS23: glans of male genital tubercle Strong Regionally restricted 9C Expression was strong in the glans ectoderm.
Specimen 9D: embryonic day 15.5; Hoxa13tm1.1Mrc/Hoxa13tm1.1Mrc (more )
Note: Double labeled: red - Ar; green - Hoxa13 reporter (assay MGI:2681891).
Structure Level Pattern Image Note
TS23: genital tubercle of male Trace Regionally restricted 9D Expression was reduced or absent in the mesenchyme adjacent to the urethral plate epithelium.
TS23: glans of male genital tubercle Present Regionally restricted 9D Expression was present in the lateral glans mesenchyme and reduced in the surface ectoderm compared to wild type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
MGI 6.23 		The Jackson Laboratory