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Trpm6 Gene Detail
Summary
  • Symbol
    Trpm6
  • Name
    transient receptor potential cation channel, subfamily M, member 6
  • Synonyms
    CHAK2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2675603
    NCBI Gene: 225997
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:18727347-18869875 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 13.21 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    5046 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2675603
 protein coding gene Chr19:18707566-18869885 (+)
129S1/SvImJ ENSMUSG00200020017
 protein coding gene Chr19:15411868-15554561 (+)
A/J ENSMUSG00195015628
 protein coding gene Chr19:15563345-15704605 (+)
AKR/J ENSMUSG00220010390
 protein coding gene Chr19:15541918-15685959 (+)
BALB/cJ ENSMUSG00180018354
 protein coding gene Chr19:15932390-16073775 (+)
C3H/HeJ ENSMUSG00175003725
 protein coding gene Chr19:15271631-15412862 (+)
C57BL/6NJ ENSMUSG00215013758
 protein coding gene Chr19:15333705-15476250 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022807
 protein coding gene Chr19:16067320-16219583 (+)
CAST/EiJ ENSTCUG00005008365
 protein coding gene Chr19:15175958-15329808 (+)
CBA/J ENSMUSG00210012642
 protein coding gene Chr19:15506162-15647413 (+)
DBA/2J ENSMUSG00185013024
 protein coding gene Chr19:15921468-16064207 (+)
FVB/NJ ENSMUSG00205003396
 protein coding gene Chr19:15335794-15478490 (+)
JF1/MsJ ENSUMUG00000017975
 protein coding gene Chr19:16164848-16317058 (+)
LP/J ENSMUSG00230016383
 protein coding gene Chr19:16781042-16923719 (+)
NOD/ShiLtJ ENSMUSG00190019291
 protein coding gene Chr19:15286809-15428054 (+)
NZO/HlLtJ ENSMUSG00225033749
 protein coding gene Chr19:20534183-20686416 (+)
PWK/PhJ ENSLUMG00010008433
 protein coding gene Chr19:15482707-15643756 (+)
SPRET/EiJ ENSMSPG00010018066
 protein coding gene Chr19:15482561-15637515 (+)
WSB/EiJ ENSIUOG00005007038
 protein coding gene Chr19:15012597-15161887 (+)



Homology
more
  • Human Ortholog
    TRPM6, transient receptor potential cation channel subfamily M member 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRPM6, transient receptor potential cation channel subfamily M member 6
  • Synonyms
    CHAK2, HMGX, HOMG, HOMG1, HSH
  • Links
    NCBI Gene ID: 140803
    UniProt: Q9BX84

  • Chr Location
    9q21.13; chr9:74722495-74888094 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human TRPM6 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic and postnatal lethality with exencephaly, spina bifida occulta, and abnormal brain and facial development. Mice heterozygous for a knock-out allele exhibit some premature death and decreased serummagnesium.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    667
  • Tissues
    42
  • cDNA Data
    23
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024727 Ensembl Gene Model | MGI Sequence Detail 142529 C57BL/6J ±  kb
    transcript ENSMUST00000040489 Ensembl | MGI Sequence Detail 6509 Not Applicable  
    polypeptide ENSMUSP00000037443 Ensembl | MGI Sequence Detail 2028 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000016702 transient receptor potential cation channel subfamily M member 6
      (term hierarchy)
    • EC
      2.7.11.1
    • InterPro Domains
      IPR004166 Alpha-type protein kinase, alpha-kinase domain
      IPR056336 Calcium channel YVC1-like, C-terminal transmembrane domain
      IPR011009 Protein kinase-like domain superfamily
      IPR050927 Transient receptor potential cation channel subfamily M
      IPR029597 Transient receptor potential cation channel subfamily M member 6, alpha-kinase domain
      IPR057366 TRPM-like domain
      IPR041491 TRPM, SLOG domain
      IPR032415 TRPM, tetramerisation domain
      IPR037162 TRPM, tetramerisation domain superfamily
    • GlyGen
      Q8CIR4 1 site
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 23
      Primer pair 6
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 10
      Gene Ontology 11
      Phenotypes 15
    • Earliest
      J:78800 Ryazanov AG, et al., Alpha-kinases: a new class of protein kinases with a novel catalytic domain. Curr Biol. 1999 Jan 28;9(2):R43-5
    • Latest
      J:363261 He T, et al., Endothelial PD-1 Regulates Vascular Homeostasis and Oligodendrogenesis during Brain Development. Adv Sci (Weinh). 2025 Feb 27;:e2417410
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory