About   Help   FAQ
Arhgap33 Gene Detail
Summary
  • Symbol
    Arhgap33
  • Name
    Rho GTPase activating protein 33
  • Synonyms
    NOMA-GAP, Snx26, Tcgap
  • Feature Type
    protein coding gene
  • IDs
    MGI:2673998
    NCBI Gene: 233071
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30221651-30234485 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 18.43 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    304 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2673998
 protein coding gene Chr7:30221651-30234596 (-)
129S1/SvImJ ENSMUSG00200039914
 protein coding gene Chr7:20001982-20014718 (-)
A/J ENSMUSG00195044679
 protein coding gene Chr7:22671009-22683773 (-)
AKR/J ENSMUSG00220045757
 protein coding gene Chr7:21797482-21810225 (+)
BALB/cJ ENSMUSG00180015836
 protein coding gene Chr7:20730482-20743246 (-)
C3H/HeJ ENSMUSG00175029785
 protein coding gene Chr7:21810680-21823512 (-)
C57BL/6NJ ENSMUSG00215052456
 protein coding gene Chr7:19912805-19925639 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029524
 protein coding gene Chr7:29755835-29768287 (-)
CAST/EiJ ENSTCUG00005041346
 protein coding gene Chr7:21711578-21724463 (-)
CBA/J ENSMUSG00210025267
 protein coding gene Chr7:20973292-20986124 (-)
DBA/2J ENSMUSG00185046959
 protein coding gene Chr7:24061632-24074451 (-)
FVB/NJ ENSMUSG00205011107
 protein coding gene Chr7:20722307-20735137 (-)
JF1/MsJ ENSUMUG00000055797
 protein coding gene Chr7:28506908-28519785 (-)
LP/J ENSMUSG00230052079
 protein coding gene Chr7:29232082-29244901 (-)
NOD/ShiLtJ ENSMUSG00190007800
 protein coding gene Chr7:20395547-20408303 (-)
NZO/HlLtJ ENSMUSG00225025796
 protein coding gene Chr7:28071962-28085188 (-)
PWK/PhJ ENSLUMG00010018243
 protein coding gene Chr7:20438288-20451163 (-)
SPRET/EiJ ENSMSPG00010033327
 protein coding gene Chr7:19800361-19813022 (-)
WSB/EiJ ENSIUOG00005048116
 protein coding gene Chr7:14683528-14696272 (-)



Homology
more
  • Human Ortholog
    ARHGAP33, Rho GTPase activating protein 33
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGAP33, Rho GTPase activating protein 33
  • Synonyms
    NOMA-GAP, SNX26, TCGAP
  • Links
    NCBI Gene ID: 115703
    UniProt: O14559

  • Chr Location
    19q13.12; chr19:35774532-35788822 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display region specific thinning of the cerebral cortex with reduced dendritic complexity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    669
  • Tissues
    21
  • cDNA Data
    111
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036882 Ensembl Gene Model | MGI Sequence Detail 12835 C57BL/6J ±  kb
    transcript ENSMUST00000207860 Ensembl | MGI Sequence Detail 4396 Not Applicable  
    polypeptide ENSMUSP00000146602 Ensembl | MGI Sequence Detail 1305 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 111
      cDNA 111
      Antibodies 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2142229
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:83822 Chiang SH, et al., TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport. EMBO J. 2003 Jun 1;22(11):2679-91
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory