About   Help   FAQ
Wfdc16 Gene Detail
Summary
  • Symbol
    Wfdc16
  • Name
    WAP four-disulfide core domain 16
  • Feature Type
    protein coding gene
  • IDs
    MGI:2670994
    NCBI Gene: 277345
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164476627-164480716 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 85.23 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    241 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2670994
 protein coding gene Chr2:164476621-164480728 (-)
129S1/SvImJ ENSMUSG00200016106
 protein coding gene Chr2:161363896-161367988 (-)
A/J ENSMUSG00195019115
 protein coding gene Chr2:161696775-161700883 (-)
AKR/J ENSMUSG00220013458
 protein coding gene Chr2:161026254-161030338 (-)
BALB/cJ ENSMUSG00180047747
 protein coding gene Chr2:161150519-161154627 (-)
C3H/HeJ ENSMUSG00175046620
 protein coding gene Chr2:161896800-161900883 (-)
C57BL/6NJ ENSMUSG00215024127
 protein coding gene Chr2:161348534-161352624 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024656
 protein coding gene Chr2:156580247-156584324 (-)
CAST/EiJ ENSTCUG00005044681
 protein coding gene Chr2:160267266-160271382 (-)
CBA/J ENSMUSG00210016432
 protein coding gene Chr2:161831174-161835281 (-)
DBA/2J ENSMUSG00185046190
 protein coding gene Chr2:161563995-161568079 (-)
FVB/NJ ENSMUSG00205022706
 protein coding gene Chr2:160584857-160588940 (-)
JF1/MsJ ENSUMUG00000025628
 protein coding gene Chr2:161208763-161212869 (-)
LP/J ENSMUSG00230039273
 protein coding gene Chr2:163125018-163129109 (-)
NOD/ShiLtJ ENSMUSG00190027969
 protein coding gene Chr2:161236004-161240111 (-)
NZO/HlLtJ ENSMUSG00225050533
 protein coding gene Chr2:171126314-171130398 (-)
PWK/PhJ ENSLUMG00010044522
 protein coding gene Chr2:161111438-161115531 (-)
SPRET/EiJ ENSMSPG00010025645
 protein coding gene Chr2:163875956-163880030 (-)
WSB/EiJ ENSIUOG00005045195
 protein coding gene Chr2:160957038-160961120 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000070530 Ensembl Gene Model | MGI Sequence Detail 4090 C57BL/6J ±  kb
transcript ENSMUST00000109336 Ensembl | MGI Sequence Detail 1116 Not Applicable  
polypeptide ENSMUSP00000104960 Ensembl | MGI Sequence Detail 111 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR036645 Elafin-like superfamily
    IPR008197 WAP-type 'four-disulfide core' domain
Molecular
Reagents
less
  • All nucleic 5
    Genomic 2
    cDNA 3

    Microarray probesets 1
References
more
  • Summaries
    All 16
    Gene Ontology 2
  • Earliest
    J:99265 Clauss A, et al., The evolution of a genetic locus encoding small serine proteinase inhibitors. Biochem Biophys Res Commun. 2005 Jul 29;333(2):383-9
  • Latest
    J:300068 Andrade AD, et al., Lipopolysaccharide-induced epididymitis modifies the transcriptional profile of Wfdc genes in mice. Biol Reprod. 2021 Jan 4;104(1):144-158
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory