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Mark1 Gene Detail
Summary
  • Symbol
    Mark1
  • Name
    MAP/microtubule affinity regulating kinase 1
  • Synonyms
    B930025N23Rik, Emk3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2664902
    NCBI Gene: 226778
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr1:184628986-184731767 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 89.26 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3267 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2664902
 protein coding gene Chr1:184628621-184732152 (-)
129S1/SvImJ ENSMUSG00200021839
 protein coding gene Chr1:182416681-182519352 (-)
A/J ENSMUSG00195040293
 protein coding gene Chr1:181999575-182102267 (-)
AKR/J ENSMUSG00220019242
 protein coding gene Chr1:181215188-181322604 (-)
BALB/cJ ENSMUSG00180036671
 protein coding gene Chr1:182065789-182168464 (-)
C3H/HeJ ENSMUSG00175033018
 protein coding gene Chr1:182241218-182343886 (-)
C57BL/6NJ ENSMUSG00215025356
 protein coding gene Chr1:181444240-181547030 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015019
 protein coding gene Chr1:174773645-174874239 (-)
CAST/EiJ ENSTCUG00005040388
 protein coding gene Chr1:180004288-180109170 (-)
CBA/J ENSMUSG00210019015
 protein coding gene Chr1:181892387-181995381 (-)
DBA/2J ENSMUSG00185032779
 protein coding gene Chr1:186507083-186610012 (-)
FVB/NJ ENSMUSG00205032131
 protein coding gene Chr1:180933995-181036567 (-)
JF1/MsJ ENSUMUG00000003086
 protein coding gene Chr1:185509388-185614137 (-)
LP/J ENSMUSG00230020105
 protein coding gene Chr1:186073231-186175897 (-)
NOD/ShiLtJ ENSMUSG00190025647
 protein coding gene Chr1:181915570-182018247 (-)
NZO/HlLtJ ENSMUSG00225009381
 protein coding gene Chr1:189802888-189905674 (-)
PWK/PhJ ENSLUMG00010015730
 protein coding gene Chr1:180763575-180866255 (-)
SPRET/EiJ ENSMSPG00010021874
 protein coding gene Chr1:184264956-184366829 (-)
WSB/EiJ ENSIUOG00005010290
 protein coding gene Chr1:181103803-181206743 (-)



Homology
more
  • Human Ortholog
    MARK1, microtubule affinity regulating kinase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MARK1, microtubule affinity regulating kinase 1
  • Synonyms
    MARK, Par-1c, Par1c
  • Links
    NCBI Gene ID: 4139
    UniProt: Q9P0L2

  • Chr Location
    1q41; chr1:220528086-220664461 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from multigenic genotypes
    5 phenotype references
Mice homozygous for a knock-out allele exhibit no obvious defects in lung epithelium morphology or apical cytoskeletal organization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    82
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    625
  • Tissues
    4
  • cDNA Data
    58
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026620 Ensembl Gene Model | MGI Sequence Detail 102782 C57BL/6J ±  kb
transcript ENSMUST00000027929 Ensembl | MGI Sequence Detail 4221 Not Applicable  
polypeptide ENSMUSP00000027929 Ensembl | MGI Sequence Detail 795 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 60
    Genomic 2
    cDNA 58

    Microarray probesets 8
Other
Accession IDs
less
MGI:2138592
References
more
  • Summaries
    All 44
    Developmental Gene Expression 4
    Gene Ontology 11
    Phenotypes 5
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:366418 Kelly-Castro EC, et al., MARK1 regulates dendritic spine morphogenesis and cognitive functions in vivo. Exp Neurol. 2024 Mar 12;376:114752
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory