Acvr1c MGI Mouse Gene Detail - MGI:2661081 - activin A receptor, type IC

Symbol

Acvr1c
Name

activin A receptor, type IC
Synonyms

Alk-7, ALK7

Feature Type

protein coding gene
IDs

MGI:2661081
NCBI Gene: 269275
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:58157465-58247907 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 33.05 cM
Mapping Data

1 experiment

SNPs within 2kb

2239 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2661081	protein coding gene	Chr2:58157465-58247909 (-)
129S1/SvImJ	ENSMUSG00200002381	protein coding gene	Chr2:55220920-55311528 (-)
A/J	ENSMUSG00195005007	protein coding gene	Chr2:55341328-55431946 (-)
AKR/J	ENSMUSG00220007075	protein coding gene	Chr2:55443318-55533939 (-)
BALB/cJ	ENSMUSG00180018569	protein coding gene	Chr2:55297967-55388432 (-)
C3H/HeJ	ENSMUSG00175012756	protein coding gene	Chr2:55366333-55456938 (-)
C57BL/6NJ	ENSMUSG00215005990	protein coding gene	Chr2:55351447-55441884 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023571	protein coding gene	Chr2:53175851-53259173 (-)
CAST/EiJ	ENSTCUG00005021822	protein coding gene	Chr2:54697721-54786023 (-)
CBA/J	ENSMUSG00210031864	protein coding gene	Chr2:55385798-55476390 (-)
DBA/2J	ENSMUSG00185007377	protein coding gene	Chr2:55241774-55332378 (-)
FVB/NJ	ENSMUSG00205016166	protein coding gene	Chr2:54880326-54970948 (-)
JF1/MsJ	ENSUMUG00000014845	protein coding gene	Chr2:54928731-55022203 (-)
LP/J	ENSMUSG00230001324	protein coding gene	Chr2:57104836-57195300 (-)
NOD/ShiLtJ	ENSMUSG00190042563	protein coding gene	Chr2:55323135-55413740 (-)
NZO/HlLtJ	ENSMUSG00225000782	protein coding gene	Chr2:64824250-64914780 (-)
PWK/PhJ	ENSLUMG00010005046	protein coding gene	Chr2:55094797-55182345 (-)
SPRET/EiJ	ENSMSPG00010011364	protein coding gene	Chr2:56220331-56300617 (-)
WSB/EiJ	ENSIUOG00005027556	protein coding gene	Chr2:55335385-55425973 (-)

Human Ortholog

ACVR1C, activin A receptor type 1C

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACVR1C, activin A receptor type 1C
Synonyms

ACVRLK7, ALK7
Links

HGNC:18123

NCBI Gene ID: 130399

UniProt: Q8NER5
Chr Location

2q24.1; chr2:157526767-157628885 (-) GRCh38

MGI Vertebrate Homology

Acvr1c stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ACVR1C
Gene Tree

Acvr1c

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Phenotype Summary

4 phenotypes from 2 alleles in 3 genetic backgrounds
2 phenotypes from multigenic genotypes
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

8
Targeted

7
Genomic Mutations

1 involving Acvr1c
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

39 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable, fertile, and overtly normal with no apparent left-right patterning abnormalities or organogenesis defects.

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All GO Annotations

84
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

734
Tissues

69
cDNA Data

8
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase acvr1c

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All Sequences

56
RefSeq

11
UniProt

7
CCDS

CCDS16049.1, CCDS50586.1

Ensembl

ENSMUSG00000026834 (Evidence)
NCBI Gene

269275

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026834	Ensembl Gene Model \| MGI Sequence Detail	90443	C57BL/6J	± kb
transcript	ENSMUST00000028178	Ensembl \| MGI Sequence Detail	9162	Not Applicable
polypeptide	ENSMUSP00000028178	Ensembl \| MGI Sequence Detail	493	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000000069 activin receptor type-1C

(term hierarchy)
EC

2.7.11.1, 2.7.11.30
InterPro Domains

IPR000472 Activin types I and II receptor domain

IPR003605 GS domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR000333 Ser/Thr protein kinase, TGFB receptor

IPR045860 Snake toxin-like superfamily
GlyGen

Q8K348 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 13

cDNA 8

Primer pair 4

Other 1

Microarray probesets 5

Summaries

All 74

Developmental Gene Expression 12

Gene Ontology 16

Phenotypes 21
Earliest

J:87407 Dudas M, et al., Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway. Dev Biol. 2004 Feb 1;266(1):96-108
Latest

J:350728 Zheng Y, et al., Targeting the activin receptor 1C on CD4+ T cells for cancer immunotherapy. Oncoimmunology. 2024;13(1):2297503

TSS for Acvr1c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr24152	Chr2:58247790-58247829 (-)	97 bp
Tssr24151	Chr2:58158045-58158049 (-)	89,860 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24