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Fam171a2 Gene Detail
Summary
  • Symbol
    Fam171a2
  • Name
    family with sequence similarity 171, member A2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448496
    NCBI Gene: 217219
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:102327807-102338508 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 66.29 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    246 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2448496
 protein coding gene Chr11:102327807-102338551 (-)
129S1/SvImJ ENSMUSG00200051931
 protein coding gene Chr11:99614146-99624826 (-)
A/J ENSMUSG00195049935
 protein coding gene Chr11:99319461-99330213 (-)
AKR/J ENSMUSG00220049758
 protein coding gene Chr11:99529534-99540233 (-)
BALB/cJ ENSMUSG00180049569
 protein coding gene Chr11:99661805-99672486 (-)
C3H/HeJ ENSMUSG00175051395
 protein coding gene Chr11:99587674-99598350 (-)
C57BL/6NJ ENSMUSG00215050795
 protein coding gene Chr11:99149694-99160399 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017253
 protein coding gene Chr11:98391277-98401640 (-)
CAST/EiJ ENSTCUG00005046510
 protein coding gene Chr11:99088438-99099174 (-)
CBA/J ENSMUSG00210052816
 protein coding gene Chr11:99295495-99306197 (-)
DBA/2J ENSMUSG00185050301
 protein coding gene Chr11:99637541-99648223 (-)
FVB/NJ ENSMUSG00205042314
 protein coding gene Chr11:99480426-99491134 (-)
JF1/MsJ ENSUMUG00000055121
 protein coding gene Chr11:99899837-99910555 (-)
LP/J ENSMUSG00230049721
 protein coding gene Chr11:100690061-100700739 (-)
NOD/ShiLtJ ENSMUSG00190043820
 protein coding gene Chr11:99676045-99686738 (-)
NZO/HlLtJ ENSMUSG00225050178
 protein coding gene Chr11:102712696-102723392 (-)
PWK/PhJ ENSLUMG00010046969
 protein coding gene Chr11:99433778-99444464 (-)
SPRET/EiJ ENSMSPG00010050218
 protein coding gene Chr11:99931389-99942128 (-)
WSB/EiJ ENSIUOG00005048383
 protein coding gene Chr11:99431167-99441850 (-)



Homology
more
  • Human Ortholog
    FAM171A2, family with sequence similarity 171 member A2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FAM171A2, family with sequence similarity 171 member A2
  • Links
    NCBI Gene ID: 284069
    UniProt: A8MVW0

  • Chr Location
    17q21.31; chr17:44353215-44363868 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display lethality. Mice with heterozygous or neuron specific loss of expression show reduced susceptibility to alpha-synuclein fibril neurotoxicity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034685 Ensembl Gene Model | MGI Sequence Detail 10702 C57BL/6J ±  kb
    transcript ENSMUST00000049057 Ensembl | MGI Sequence Detail 3118 Not Applicable  
    polypeptide ENSMUSP00000038486 Ensembl | MGI Sequence Detail 822 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 20

      Microarray probesets 2
    References
    more
    • Summaries
      All 30
      Gene Ontology 1
      Phenotypes 12
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:362731 Wu KM, et al., Neuronal FAM171A2 mediates alpha-synuclein fibril uptake and drives Parkinson's disease. Science. 2025 Feb 21;387(6736):892-900
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory