Cracr2b MGI Mouse Gene Detail - MGI:2446129 - calcium release activated channel regulator 2B

Symbol

Cracr2b
Name

calcium release activated channel regulator 2B
Synonyms

6330520A15Rik, Efcab4a

Feature Type

protein coding gene
IDs

MGI:2446129
NCBI Gene: 213573
Alliance

genome feature page
Transcription Start Sites

17 TSS

Sequence Map

Chr7:141041007-141046526 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 86.82 cM
Mapping Data

2 experiments

SNPs within 2kb

165 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2446129	protein coding gene	Chr7:141041007-141046526 (+)
129S1/SvImJ	ENSMUSG00200042107	protein coding gene	Chr7:127608608-127612110 (+)
A/J	ENSMUSG00195034696	protein coding gene	Chr7:132091098-132094600 (+)
AKR/J	ENSMUSG00220031912	protein coding gene	Chr7:125572771-125576273 (+)
BALB/cJ	ENSMUSG00180031155	protein coding gene	Chr7:128783255-128786757 (+)
C3H/HeJ	ENSMUSG00175039718	protein coding gene	Chr7:129511514-129515016 (+)
C57BL/6NJ	ENSMUSG00215046056	protein coding gene	Chr7:128778096-128781599 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030700	protein coding gene	Chr7:143666306-143671925 (+)
CAST/EiJ	ENSTCUG00005050484	protein coding gene	Chr7:132083262-132086774 (+)
CBA/J	ENSMUSG00210028255	protein coding gene	Chr7:129269513-129273015 (+)
DBA/2J	ENSMUSG00185016511	protein coding gene	Chr7:133548058-133551560 (+)
FVB/NJ	ENSMUSG00205029034	protein coding gene	Chr7:129190336-129193838 (+)
JF1/MsJ	ENSUMUG00000018073	protein coding gene	Chr7:138626040-138629532 (+)
LP/J	ENSMUSG00230039055	protein coding gene	Chr7:139711518-139715020 (+)
NOD/ShiLtJ	ENSMUSG00190018241	protein coding gene	Chr7:129376963-129380463 (+)
NZO/HlLtJ	ENSMUSG00225051917	protein coding gene	Chr7:137920705-137924206 (+)
PWK/PhJ	ENSLUMG00010040592	protein coding gene	Chr7:127756926-127760416 (+)
SPRET/EiJ	ENSMSPG00010041997	protein coding gene	Chr7:129198764-129204298 (+)
WSB/EiJ	ENSIUOG00005032942	protein coding gene	Chr7:130110515-130114016 (+)

Human Ortholog

CRACR2B, calcium release activated channel regulator 2B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CRACR2B, calcium release activated channel regulator 2B
Synonyms

EFCAB4A
Links

HGNC:28703

NCBI Gene ID: 283229

UniProt: Q8N4Y2
Chr Location

11p15.5; chr11:826144-831993 (+) GRCh38

MGI Vertebrate Homology

Cracr2b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CRACR2B
Gene Tree

Cracr2b

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Phenotype Summary

6 phenotype references

All Mutations and Alleles

5
Radiation induced

1
Targeted

4
Genomic Mutations

1 involving Cracr2b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available

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All GO Annotations

5
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

38

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cracr2b

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All Sequences

57
RefSeq

8
UniProt

7
CCDS

CCDS22016.1

Ensembl

ENSMUSG00000048200 (Evidence)
NCBI Gene

213573

			Length	Strain/Species	Flank
genomic	213573	NCBI Gene Model \| MGI Sequence Detail	5520	C57BL/6J	± kb
transcript	NM_001025103	RefSeq \| MGI Sequence Detail	1687	Not Specified
polypeptide	Q80ZJ8	UniProt \| EBI \| MGI Sequence Detail	394	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000032227 EF-hand calcium-binding domain-containing protein 4A

(term hierarchy)
InterPro Domains

IPR051111 Calcium-binding regulatory protein

IPR060741 EFCAB4A/Rab-44, helical region

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

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All nucleic 38

cDNA 38

Microarray probesets 2

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MGI:1925677

Summaries

All 34

Gene Ontology 5

Phenotypes 6
Earliest

J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Cracr2b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr69973	Chr7:141039129-141039143 (+)	-1,871 bp
Tssr69974	Chr7:141039313-141039322 (+)	-1,689 bp
Tssr69975	Chr7:141039410-141039423 (+)	-1,590 bp
Tssr69976	Chr7:141039430-141039442 (+)	-1,571 bp
Tssr69977	Chr7:141039523-141039539 (+)	-1,476 bp
Tssr69978	Chr7:141039554-141039577 (+)	-1,441 bp
Tssr69979	Chr7:141039599-141039608 (+)	-1,403 bp
Tssr69980	Chr7:141039801-141039833 (+)	-1,190 bp
Tssr69981	Chr7:141040835-141040864 (+)	-157 bp
Tssr69982	Chr7:141040897-141040921 (+)	-98 bp
Tssr69983	Chr7:141040988-141041014 (+)	-6 bp
Tssr69984	Chr7:141041018-141041050 (+)	27 bp
Tssr69985	Chr7:141041641-141041670 (+)	649 bp
Tssr69986	Chr7:141042634-141042636 (+)	1,628 bp
Tssr69987	Chr7:141043942-141044002 (+)	2,965 bp
Tssr69988	Chr7:141044006-141044026 (+)	3,009 bp
Tssr69989	Chr7:141045012-141045046 (+)	4,022 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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