Lrrc25 MGI Mouse Gene Detail - MGI:2445284 - leucine rich repeat containing 25

Symbol

Lrrc25
Name

leucine rich repeat containing 25
Synonyms

Mapa

Feature Type

protein coding gene
IDs

MGI:2445284
NCBI Gene: 211228
Alliance

genome feature page
Transcription Start Sites

13 TSS

Sequence Map

Chr8:71068810-71073501 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 34.15 cM
Mapping Data

1 experiment

SNPs within 2kb

201 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2445284	protein coding gene	Chr8:71068805-71074133 (+)
129S1/SvImJ	ENSMUSG00200026226	protein coding gene	Chr8:65865887-65871257 (+)
A/J	ENSMUSG00195013553	protein coding gene	Chr8:66199639-66204969 (+)
AKR/J	ENSMUSG00220021062	protein coding gene	Chr8:66111314-66116687 (+)
BALB/cJ	ENSMUSG00180024775	protein coding gene	Chr8:65842304-65847677 (+)
C3H/HeJ	ENSMUSG00175021143	protein coding gene	Chr8:66122230-66127600 (+)
C57BL/6NJ	ENSMUSG00215034553	protein coding gene	Chr8:65802118-65807446 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031155	protein coding gene	Chr8:62832855-62836746 (+)
CAST/EiJ	ENSTCUG00005039404	protein coding gene	Chr8:65597345-65602684 (+)
CBA/J	ENSMUSG00210030412	protein coding gene	Chr8:65887798-65893168 (+)
DBA/2J	ENSMUSG00185012832	protein coding gene	Chr8:72047401-72052772 (+)
FVB/NJ	ENSMUSG00205031314	protein coding gene	Chr8:65392027-65397399 (+)
JF1/MsJ	ENSUMUG00000034780	protein coding gene	Chr8:74327937-74333272 (+)
LP/J	ENSMUSG00230029400	protein coding gene	Chr8:75658955-75664325 (+)
NOD/ShiLtJ	ENSMUSG00190024364	protein coding gene	Chr8:65809242-65814570 (+)
NZO/HlLtJ	ENSMUSG00225047598	protein coding gene	Chr8:79068111-79073481 (+)
PWK/PhJ	ENSLUMG00010030809	protein coding gene	Chr8:65784957-65790283 (+)
SPRET/EiJ	ENSMSPG00010031195	protein coding gene	Chr8:67472116-67477151 (+)
WSB/EiJ	ENSIUOG00005023842	protein coding gene	Chr8:66678870-66684242 (+)

Human Ortholog

LRRC25, leucine rich repeat containing 25

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LRRC25, leucine rich repeat containing 25
Synonyms

MAPA
Links

HGNC:29806

NCBI Gene ID: 126364

UniProt: Q8N386
Chr Location

19p13.11; chr19:18391137-18397622 (-) GRCh38

MGI Vertebrate Homology

Lrrc25 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: LRRC25
Gene Tree

Lrrc25

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

2
Targeted

2
Genomic Mutations

1 involving Lrrc25
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

16
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

7

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

36
RefSeq

4
UniProt

3
CCDS

CCDS22375.1

Ensembl

ENSMUSG00000049988 (Evidence)
NCBI Gene

211228

			Length	Strain/Species	Flank
genomic	211228	NCBI Gene Model \| MGI Sequence Detail	4692	C57BL/6J	± kb
transcript	NM_153074	RefSeq \| MGI Sequence Detail	1263	C57BL/6
polypeptide	Q8K1T1	UniProt \| EBI \| MGI Sequence Detail	297	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009934 leucine-rich repeat-containing protein 25

(term hierarchy)
InterPro Domains

IPR001611 Leucine-rich repeat

IPR039243 Leucine-rich repeat-containing protein 25

IPR032675 Leucine-rich repeat domain superfamily
GlyGen

Q8K1T1 4 sites

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All nucleic 7

cDNA 7

Microarray probesets 1

Summaries

All 27

Gene Ontology 4

Phenotypes 7
Earliest

J:80026 Rissoan MC, et al., Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells. Blood. 2002 Nov 1;100(9):3295-303
Latest

J:270157 Zhang X, et al., Loss of LRRC25 accelerates pathological cardiac hypertrophy through promoting fibrosis and inflammation regulated by TGF-beta1. Biochem Biophys Res Commun. 2018 Nov 17;506(1):137-144

TSS for Lrrc25:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr77779	Chr8:71068752-71068763 (+)	-52 bp
Tssr77780	Chr8:71068764-71068790 (+)	-33 bp
Tssr77781	Chr8:71068797-71068811 (+)	-6 bp
Tssr77782	Chr8:71069316-71069334 (+)	515 bp
Tssr77783	Chr8:71069466-71069580 (+)	713 bp
Tssr77784	Chr8:71069587-71069598 (+)	783 bp
Tssr77785	Chr8:71069625-71069636 (+)	821 bp
Tssr77786	Chr8:71070371-71070390 (+)	1,571 bp
Tssr77787	Chr8:71070447-71070479 (+)	1,653 bp
Tssr77788	Chr8:71070562-71070620 (+)	1,781 bp
Tssr77789	Chr8:71070741-71070757 (+)	1,939 bp
Tssr77790	Chr8:71070787-71070820 (+)	1,994 bp
Tssr77791	Chr8:71071833-71071843 (+)	3,028 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29