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Lrrn4 Gene Detail
Summary
  • Symbol
    Lrrn4
  • Name
    leucine rich repeat neuronal 4
  • Synonyms
    B430119L13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445154
    NCBI Gene: 320974
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:132710225-132722811 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 64.78 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    504 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445154
 protein coding gene Chr2:132710225-132735930 (-)
129S1/SvImJ ENSMUSG00200047048
 protein coding gene Chr2:129763176-129775754 (-)
A/J ENSMUSG00195028017
 protein coding gene Chr2:129788259-129800845 (-)
AKR/J ENSMUSG00220044444
 protein coding gene Chr2:129561273-129573855 (-)
BALB/cJ ENSMUSG00180045739
 protein coding gene Chr2:129606820-129619410 (-)
C3H/HeJ ENSMUSG00175042697
 protein coding gene Chr2:130149884-130162439 (-)
C57BL/6NJ ENSMUSG00215023816
 protein coding gene Chr2:129636187-129648773 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024347
 protein coding gene Chr2:125652032-125664676 (-)
CAST/EiJ ENSTCUG00005039536
 protein coding gene Chr2:128918423-128931103 (-)
CBA/J ENSMUSG00210030945
 protein coding gene Chr2:130006350-130018905 (-)
DBA/2J ENSMUSG00185034906
 protein coding gene Chr2:129648055-129660641 (-)
FVB/NJ ENSMUSG00205034119
 protein coding gene Chr2:128822273-128834860 (-)
JF1/MsJ ENSUMUG00000010475
 protein coding gene Chr2:129467338-129480108 (-)
LP/J ENSMUSG00230038146
 protein coding gene Chr2:131399384-131411940 (-)
NOD/ShiLtJ ENSMUSG00190013341
 protein coding gene Chr2:129729261-129741846 (-)
NZO/HlLtJ ENSMUSG00225027272
 protein coding gene Chr2:139307189-139319775 (-)
PWK/PhJ ENSLUMG00010041101
 protein coding gene Chr2:129471361-129484242 (-)
SPRET/EiJ ENSMSPG00010025434
 protein coding gene Chr2:131842163-131853989 (-)
WSB/EiJ ENSIUOG00005041090
 protein coding gene Chr2:129576912-129589478 (-)



Homology
more
  • Human Ortholog
    LRRN4, leucine rich repeat neuronal 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRRN4, leucine rich repeat neuronal 4
  • Synonyms
    C20orf75, dJ1056H1.1, NLRR-4, NLRR4
  • Links
    NCBI Gene ID: 164312
    UniProt: Q8WUT4

  • Chr Location
    20p12.3; chr20:6037376-6060313 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutant mice exhibit impaired memory retention in hippocampus- dependent learning tasks such as contextual conditioning and spatial learning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    40
  • cDNA Data
    7
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000043110 Ensembl Gene Model | MGI Sequence Detail 12587 C57BL/6J ±  kb
transcript ENSMUST00000049787 Ensembl | MGI Sequence Detail 3715 Not Applicable  
polypeptide ENSMUSP00000057005 Ensembl | MGI Sequence Detail 733 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 7
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 34
    Developmental Gene Expression 5
    Gene Ontology 3
    Phenotypes 13
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:332240 Feng W, et al., Single-cell transcriptomic analysis identifies murine heart molecular features at embryonic and neonatal stages. Nat Commun. 2022 Dec 27;13(1):7960
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory