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Fsd2 Gene Detail
Summary
  • Symbol
    Fsd2
  • Name
    fibronectin type III and SPRY domain containing 2
  • Synonyms
    9830160G03Rik, Spryd1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444310
    NCBI Gene: 244091
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:81184102-81216729 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 45.71 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1283 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444310
 protein coding gene Chr7:81183056-81216729 (-)
129S1/SvImJ ENSMUSG00200033145
 protein coding gene Chr7:68002704-68036343 (-)
A/J ENSMUSG00195039546
 protein coding gene Chr7:72426445-72460084 (-)
AKR/J ENSMUSG00220031131
 protein coding gene Chr7:65961289-65994927 (-)
BALB/cJ ENSMUSG00180013287
 protein coding gene Chr7:69144350-69177989 (-)
C3H/HeJ ENSMUSG00175019313
 protein coding gene Chr7:69914796-69948436 (-)
C57BL/6NJ ENSMUSG00215026119
 protein coding gene Chr7:69010734-69044373 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029922
 protein coding gene Chr7:84095714-84130123 (-)
CAST/EiJ ENSTCUG00005041490
 protein coding gene Chr7:72477030-72510567 (-)
CBA/J ENSMUSG00210023285
 protein coding gene Chr7:69765951-69799591 (-)
DBA/2J ENSMUSG00185045582
 protein coding gene Chr7:74088753-74122393 (-)
FVB/NJ ENSMUSG00205015940
 protein coding gene Chr7:69662350-69695987 (-)
JF1/MsJ ENSUMUG00000022935
 protein coding gene Chr7:78757127-78790733 (-)
LP/J ENSMUSG00230011493
 protein coding gene Chr7:80178010-80211649 (-)
NOD/ShiLtJ ENSMUSG00190016362
 protein coding gene Chr7:69905791-69939431 (-)
NZO/HlLtJ ENSMUSG00225041349
 protein coding gene Chr7:78424516-78458466 (-)
PWK/PhJ ENSLUMG00010015731
 protein coding gene Chr7:68353661-68387248 (-)
SPRET/EiJ ENSMSPG00010021600
 protein coding gene Chr7:68751328-68785976 (-)
WSB/EiJ ENSIUOG00005019222
 protein coding gene Chr7:70252079-70285688 (-)



Homology
more
  • Human Ortholog
    FSD2, fibronectin type III and SPRY domain containing 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FSD2, fibronectin type III and SPRY domain containing 2
  • Synonyms
    SPRYD1
  • Links
    NCBI Gene ID: 123722
    UniProt: A1L4K1

  • Chr Location
    chr15:82755362-82806111 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 1 allele in 1 genetic background
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    606
  • Tissues
    7
  • cDNA Data
    11
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 244091 NCBI Gene Model | MGI Sequence Detail 32628 C57BL/6J ±  kb
    transcript NM_172904 RefSeq | MGI Sequence Detail 2976 C57BL/6  
    polypeptide Q8BZ52 UniProt | EBI | MGI Sequence Detail 716 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 3
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 21
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:367686 Briere A, et al., Systematic Ocular Phenotyping of Knockout Mouse Lines Identifies Genes Associated With Age-Related Corneal Dystrophies. Invest Ophthalmol Vis Sci. 2025 May 1;66(5):7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory