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Ube2o Gene Detail
Summary
  • Symbol
    Ube2o
  • Name
    ubiquitin-conjugating enzyme E2O
  • Synonyms
    B230113M03Rik, mKIAA1734
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444266
    NCBI Gene: 217342
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:116428566-116472273 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 81.42 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    964 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444266
 protein coding gene Chr11:116428500-116472281 (-)
129S1/SvImJ ENSMUSG00200049888
 protein coding gene Chr11:113790134-113832599 (-)
A/J ENSMUSG00195026298
 protein coding gene Chr11:113496780-113540502 (-)
AKR/J ENSMUSG00220024605
 protein coding gene Chr11:113599308-113643019 (-)
BALB/cJ ENSMUSG00180051304
 protein coding gene Chr11:113791306-113833770 (-)
C3H/HeJ ENSMUSG00175033178
 protein coding gene Chr11:113748544-113792265 (-)
C57BL/6NJ ENSMUSG00215041518
 protein coding gene Chr11:113288764-113332472 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017447
 protein coding gene Chr11:112388901-112445330 (-)
CAST/EiJ ENSTCUG00005033390
 protein coding gene Chr11:113149183-113192769 (-)
CBA/J ENSMUSG00210050392
 protein coding gene Chr11:113468531-113512252 (-)
DBA/2J ENSMUSG00185020998
 protein coding gene Chr11:113782761-113825224 (-)
FVB/NJ ENSMUSG00205041526
 protein coding gene Chr11:113596414-113638878 (-)
JF1/MsJ ENSUMUG00000053007
 protein coding gene Chr11:114050379-114094552 (-)
LP/J ENSMUSG00230049414
 protein coding gene Chr11:114841807-114885528 (-)
NOD/ShiLtJ ENSMUSG00190029619
 protein coding gene Chr11:113813733-113856194 (-)
NZO/HlLtJ ENSMUSG00225052405
 protein coding gene Chr11:116892078-116934539 (-)
PWK/PhJ ENSLUMG00010020404
 protein coding gene Chr11:113566650-113610848 (-)
SPRET/EiJ ENSMSPG00010040016
 protein coding gene Chr11:114085082-114127858 (-)
WSB/EiJ ENSIUOG00005042208
 protein coding gene Chr11:113555166-113597598 (-)



Homology
more
  • Human Ortholog
    UBE2O, ubiquitin conjugating enzyme E2 O
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UBE2O, ubiquitin conjugating enzyme E2 O
  • Synonyms
    E2-230K
  • Links
    NCBI Gene ID: 63893
    UniProt: Q9C0C9

  • Chr Location
    17q25.1; chr17:76389456-76453208 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased MEF proliferation and transformation and increased pre-weaning lethality. Mice heterozygous for the allele exhibit increased total body fat amount, increased startle reflex, increased grip strength and increased circulating HDL cholesterol.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    647
  • Tissues
    43
  • cDNA Data
    137
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020802 Ensembl Gene Model | MGI Sequence Detail 43708 C57BL/6J ±  kb
    transcript ENSMUST00000082152 Ensembl | MGI Sequence Detail 5205 Not Applicable  
    polypeptide ENSMUSP00000080791 Ensembl | MGI Sequence Detail 1288 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 137
      cDNA 137

      Microarray probesets 4
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 17
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:378661 Wang D, et al., UBE2O-mediated monoubiquitination licenses NLRP6 inflammasome activation in the intestine. Cell Host Microbe. 2026 Jan 14;34(1):86-102.e8
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory