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Lcor Gene Detail
Summary
  • Symbol
    Lcor
  • Name
    ligand dependent nuclear receptor corepressor
  • Synonyms
    3110023F06Rik, A630025C20Rik, Gm340, LOC381224, mKIAA1795, Mlr2, Pali1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443930
    NCBI Gene: 212391
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:41471076-41574975 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 34.97 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1841 from dbSNP Build 142
  • Strain Annotations
    31
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443930
 protein coding gene Chr19:41471076-41584600 (+)
129S1/SvImJ ENSMUSG00200027625
 protein coding gene Chr19:38302090-38307301 (+)
129S1/SvImJ ENSMUSGG00200054638
 protein coding gene Chr19:38269976-38282591 (+)
A/J ENSMUSG00195010013
 protein coding gene Chr19:38405326-38410537 (+)
A/J ENSMUSGG00195055141
 protein coding gene Chr19:38373214-38385830 (+)
AKR/J ENSMUSG00220017250
 protein coding gene Chr19:38218841-38224052 (+)
AKR/J ENSMUSGG00220054906
 protein coding gene Chr19:38186728-38199343 (+)
BALB/cJ ENSMUSG00180032275
 protein coding gene Chr19:38657736-38662947 (+)
BALB/cJ ENSMUSGG00180055318
 protein coding gene Chr19:38625622-38638239 (+)
C3H/HeJ ENSMUSG00175036957
 protein coding gene Chr19:38181102-38186313 (+)
C3H/HeJ ENSMUSGG00175054759
 protein coding gene Chr19:38148988-38161603 (+)
C57BL/6NJ ENSMUSGG00215055429
 protein coding gene Chr19:38259652-38264410 (+)
C57BL/6NJ ENSMUSG00215016772
 protein coding gene Chr19:38227512-38240134 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022951
 protein coding gene Chr19:38158683-38234490 (+)
CAST/EiJ ENSTCUG00005015239
 protein coding gene Chr19:37860219-37864981 (+)
CBA/J ENSMUSGG00210054468
 protein coding gene Chr19:38231120-38243735 (+)
CBA/J ENSMUSG00210029698
 protein coding gene Chr19:38263233-38268444 (+)
DBA/2J ENSMUSG00185030497
 protein coding gene Chr19:38783405-38788616 (+)
DBA/2J ENSMUSGG00185057600
 protein coding gene Chr19:38751291-38763906 (+)
FVB/NJ ENSMUSGG00205054294
 protein coding gene Chr19:37702448-37715062 (+)
FVB/NJ ENSMUSG00205007193
 protein coding gene Chr19:37734560-37739771 (+)
JF1/MsJ ENSUMUG00000038363
 protein coding gene Chr19:38949303-38955759 (+)
LP/J ENSMUSG00230032712
 protein coding gene Chr19:39572225-39577436 (+)
LP/J ENSMUSGG00230055594
 protein coding gene Chr19:39540112-39552727 (+)
NOD/ShiLtJ ENSMUSG00190010779
 protein coding gene Chr19:38133206-38138417 (+)
NOD/ShiLtJ ENSMUSGG00190054737
 protein coding gene Chr19:38101092-38113707 (+)
NZO/HlLtJ ENSMUSG00225042220
 protein coding gene Chr19:43130307-43135518 (+)
NZO/HlLtJ ENSMUSGG00225055377
 protein coding gene Chr19:43098195-43110810 (+)
PWK/PhJ ENSLUMG00010000766
 protein coding gene Chr19:38116715-38123183 (+)
SPRET/EiJ ENSMSPG00010018462
 protein coding gene Chr19:37848791-37855257 (+)
WSB/EiJ ENSIUOG00005033833
 protein coding gene Chr19:37640782-37645993 (+)



Homology
more
  • Human Ortholog
    LCOR, ligand dependent nuclear receptor corepressor
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LCOR, ligand dependent nuclear receptor corepressor
  • Synonyms
    C10orf12, MLR2
  • Links
    NCBI Gene ID: 84458
    UniProt: Q96JN0

  • Chr Location
    10q24.1; chr10:96831803-96995956 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die between E11.5 and birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    856
  • Tissues
    138
  • cDNA Data
    24
  • Literature Summary
    13
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025019 Ensembl Gene Model | MGI Sequence Detail 103900 C57BL/6J ±  kb
transcript ENSMUST00000238398 Ensembl | MGI Sequence Detail 5764 Not Applicable  
polypeptide ENSMUSP00000158715 Ensembl | MGI Sequence Detail 1696 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    cDNA 24
    Primer pair 2
    Other 1
    Antibodies 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:1920403, MGI:2685186
References
more
  • Summaries
    All 56
    Developmental Gene Expression 13
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:383110 Agius SC, et al., Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains. Mol Cell. 2026 Mar 19;86(6):1032-1045.e10
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory