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Rasal2 Gene Detail
Summary
  • Symbol
    Rasal2
  • Name
    RAS protein activator like 2
  • Synonyms
    A330066M24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443881
    NCBI Gene: 226525
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:156962759-157240170 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 67.97 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    5993 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443881
 protein coding gene Chr1:156962752-157240170 (-)
129S1/SvImJ ENSMUSG00200006346
 protein coding gene Chr1:154408750-154695792 (-)
A/J ENSMUSG00195019141
 protein coding gene Chr1:153785359-154062797 (-)
AKR/J ENSMUSG00220013911
 protein coding gene Chr1:153577833-153858265 (-)
BALB/cJ ENSMUSG00180031400
 protein coding gene Chr1:154004313-154282160 (-)
C3H/HeJ ENSMUSG00175038397
 protein coding gene Chr1:154049705-154330134 (-)
C57BL/6NJ ENSMUSG00215038604
 protein coding gene Chr1:153949323-154226752 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014743
 protein coding gene Chr1:147805762-148075020 (-)
CAST/EiJ ENSTCUG00005005626
 protein coding gene Chr1:152599536-152860382 (-)
CBA/J ENSMUSG00210020775
 protein coding gene Chr1:153946050-154226464 (-)
DBA/2J ENSMUSG00185044351
 protein coding gene Chr1:158224419-158502275 (-)
FVB/NJ ENSMUSG00205008950
 protein coding gene Chr1:153079941-153360128 (-)
JF1/MsJ ENSUMUG00000008918
 protein coding gene Chr1:157381024-157658946 (-)
LP/J ENSMUSG00230015043
 protein coding gene Chr1:157807844-158088405 (-)
NOD/ShiLtJ ENSMUSG00190029830
 protein coding gene Chr1:153799618-154080009 (-)
NZO/HlLtJ ENSMUSG00225005534
 protein coding gene Chr1:161459735-161737593 (-)
PWK/PhJ ENSLUMG00010040532
 protein coding gene Chr1:152739436-153017173 (-)
SPRET/EiJ ENSMSPG00010038578
 protein coding gene Chr1:156087447-156358835 (-)
WSB/EiJ ENSIUOG00005014734
 protein coding gene Chr1:153389588-153670383 (-)



Homology
more
  • Human Ortholog
    RASAL2, RAS protein activator like 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RASAL2, RAS protein activator like 2
  • Synonyms
    NGAP
  • Links
    NCBI Gene ID: 9462
    UniProt: Q9UJF2

  • Chr Location
    1q25.2; chr1:178093768-178484147 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit reduced survival and decreased tumor latency. In other tumorigenic models, this allele promotes increase metastatic potential.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    774
  • Tissues
    22
  • cDNA Data
    16
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 226525 NCBI Gene Model | MGI Sequence Detail 277412 C57BL/6J ±  kb
transcript NM_177644 RefSeq | MGI Sequence Detail 9979 C57BL/6  
polypeptide NP_808312 RefSeq | MGI Sequence Detail 1286 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • InterPro Domains
    IPR000008 C2 domain
    IPR035892 C2 domain superfamily
    IPR021887 Disabled homolog 2-interacting protein, C-terminal domain
    IPR011993 PH-like domain superfamily
    IPR001849 Pleckstrin homology domain
    IPR001936 Ras GTPase-activating domain
    IPR039360 Ras GTPase-activating protein
    IPR023152 Ras GTPase-activating protein, conserved site
    IPR057606 Ras/Rap GTPase-activating protein SynGAP-like, PH domain
    IPR008936 Rho GTPase activation protein
  • GlyGen
    E9PW37 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 16
    cDNA 16

    Microarray probesets 2
References
more
  • Summaries
    All 35
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 16
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory