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Stxbp5l Gene Detail
Summary
  • Symbol
    Stxbp5l
  • Name
    syntaxin binding protein 5-like
  • Synonyms
    A830015P08Rik, insulin level locus 1, LLGL4, T2dm1, t2md1, tomosyn-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443815
    NCBI Gene: 207227
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:36935304-37205324 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 26.32 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5740 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443815
 protein coding gene Chr16:36927437-37205377 (-)
129S1/SvImJ ENSMUSG00200027667
 protein coding gene Chr16:33871102-34141234 (-)
A/J ENSMUSG00195010297
 protein coding gene Chr16:33417531-33686552 (-)
AKR/J ENSMUSG00220025894
 protein coding gene Chr16:33795149-34064125 (-)
BALB/cJ ENSMUSG00180012351
 protein coding gene Chr16:33633139-33902184 (-)
C3H/HeJ ENSMUSG00175030175
 protein coding gene Chr16:33853499-34122520 (-)
C57BL/6NJ ENSMUSG00215016618
 protein coding gene Chr16:33706707-33976832 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020726
 protein coding gene Chr16:34152135-34450306 (-)
CAST/EiJ ENSTCUG00005028481
 protein coding gene Chr16:34131979-34416132 (-)
CBA/J ENSMUSG00210027308
 protein coding gene Chr16:33910581-34179585 (-)
DBA/2J ENSMUSG00185023338
 protein coding gene Chr16:33813610-34082617 (-)
FVB/NJ ENSMUSG00205015733
 protein coding gene Chr16:33792627-34062756 (-)
JF1/MsJ ENSUMUG00000020187
 protein coding gene Chr16:34030381-34299450 (-)
LP/J ENSMUSG00230027374
 protein coding gene Chr16:36385811-36654799 (-)
NOD/ShiLtJ ENSMUSG00190019692
 protein coding gene Chr16:33931946-34200935 (-)
NZO/HlLtJ ENSMUSG00225038833
 protein coding gene Chr16:39485156-39754131 (-)
PWK/PhJ ENSLUMG00010026808
 protein coding gene Chr16:33936282-34218565 (-)
SPRET/EiJ ENSMSPG00010016732
 protein coding gene Chr16:33921270-34193228 (-)
WSB/EiJ ENSIUOG00005026658
 protein coding gene Chr16:33989479-34268819 (-)



Homology
more
  • Human Ortholog
    STXBP5L, syntaxin binding protein 5L
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STXBP5L, syntaxin binding protein 5L
  • Synonyms
    LLGL4
  • Links
    NCBI Gene ID: 9515
    UniProt: Q9Y2K9

  • Chr Location
    3q13.33; chr3:120908072-121424761 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit background sensitive embryonic/postnatal lethality, altered motor performance and impaired NMJ neurotransmission.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    702
  • Tissues
    25
  • cDNA Data
    9
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022829 Ensembl Gene Model | MGI Sequence Detail 270021 C57BL/6J ±  kb
    transcript ENSMUST00000114787 Ensembl | MGI Sequence Detail 4394 Not Applicable  
    polypeptide ENSMUSP00000110435 Ensembl | MGI Sequence Detail 1185 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000015805 syntaxin-binding protein 5-like
      (term hierarchy)
    • InterPro Domains
      IPR000664 Lethal(2) giant larvae protein
      IPR013577 Lethal giant larvae homologue 2, N-terminal domain
      IPR013905 Lethal giant larvae (Lgl)-like, C-terminal domain
      IPR042855 v-SNARE, coiled-coil homology domain
      IPR001680 WD40 repeat
      IPR019775 WD40 repeat, conserved site
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    • GlyGen
      Q5DQR4 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2152040
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:65486 Stoehr JP, et al., Genetic obesity unmasks nonlinear interactions between murine type 2 diabetes susceptibility loci. Diabetes. 2000 Nov;49(11):1946-54
    • Latest
      J:353360 Cesari E, et al., Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development. Nucleic Acids Res. 2024 May 8;52(8):4167-4184
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory