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Scfd2 Gene Detail
Summary
  • Symbol
    Scfd2
  • Name
    Sec1 family domain containing 2
  • Synonyms
    E430013M20Rik, STXBP1L1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443446
    NCBI Gene: 212986
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:74365477-74692420 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 39.44 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    9093 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443446
 protein coding gene Chr5:74365477-74692436 (-)
129S1/SvImJ ENSMUSG00200033600
 protein coding gene Chr5:70038228-70372446 (-)
A/J ENSMUSG00195030590
 protein coding gene Chr5:69355966-69682768 (-)
AKR/J ENSMUSG00220004237
 protein coding gene Chr5:69461379-69788438 (-)
BALB/cJ ENSMUSG00180019809
 protein coding gene Chr5:69112990-69443937 (-)
C3H/HeJ ENSMUSG00175024245
 protein coding gene Chr5:71173470-71509735 (-)
C57BL/6NJ ENSMUSG00215004649
 protein coding gene Chr5:69941154-70268209 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027303
 protein coding gene Chr5:67130243-67453575 (-)
CAST/EiJ ENSTCUG00005027599
 protein coding gene Chr5:68924574-69249242 (-)
CBA/J ENSMUSG00210023099
 protein coding gene Chr5:70111544-70447814 (-)
DBA/2J ENSMUSG00185015305
 protein coding gene Chr5:71941399-72277691 (-)
FVB/NJ ENSMUSG00205018479
 protein coding gene Chr5:68879072-69205868 (-)
JF1/MsJ ENSUMUG00000004616
 protein coding gene Chr5:76425932-76762232 (-)
LP/J ENSMUSG00230019077
 protein coding gene Chr5:76612446-76946641 (-)
NOD/ShiLtJ ENSMUSG00190003983
 protein coding gene Chr5:69055238-69382281 (-)
NZO/HlLtJ ENSMUSG00225033187
 protein coding gene Chr5:81676039-82003076 (-)
PWK/PhJ ENSLUMG00010014000
 protein coding gene Chr5:68985410-69318596 (-)
SPRET/EiJ ENSMSPG00010008912
 protein coding gene Chr5:71007440-71344182 (-)
WSB/EiJ ENSIUOG00005018258
 protein coding gene Chr5:71878012-72204914 (-)



Homology
more
  • Human Ortholog
    SCFD2, sec1 family domain containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCFD2, sec1 family domain containing 2
  • Synonyms
    STXBP1L1
  • Links
    NCBI Gene ID: 152579
    UniProt: Q8WU76

  • Chr Location
    4q12; chr4:52872982-53366072 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    401 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000062110 Ensembl Gene Model | MGI Sequence Detail 326944 C57BL/6J ±  kb
    transcript ENSMUST00000072857 Ensembl | MGI Sequence Detail 3672 Not Applicable  
    polypeptide ENSMUSP00000072636 Ensembl | MGI Sequence Detail 684 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 5
    References
    more
    • Summaries
      All 421
      Diseases 1
      Gene Ontology 2
      Phenotypes 401
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:390040 Dang L, et al., Activation of Intestinal Mast Cells Contributes to Gut Damage After Cardiac Arrest in Mice. Shock. 2026 Jan 1;65(1):85-92
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory