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Nceh1 Gene Detail
Summary
  • Symbol
    Nceh1
  • Name
    neutral cholesterol ester hydrolase 1
  • Synonyms
    Aadacl1, B230106I24Rik, CPO-BP, mKIAA1363
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443191
    NCBI Gene: 320024
  • Alliance
    genome feature page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:27237153-27299112 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 10.82 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1768 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443191
 protein coding gene Chr3:27237114-27338757 (+)
129S1/SvImJ ENSMUSG00200022952
 protein coding gene Chr3:23961110-24062827 (+)
A/J ENSMUSG00195020288
 protein coding gene Chr3:24088302-24196467 (+)
AKR/J ENSMUSG00220008212
 protein coding gene Chr3:24086798-24201288 (+)
BALB/cJ ENSMUSG00180030435
 protein coding gene Chr3:24068400-24170066 (+)
C3H/HeJ ENSMUSG00175026666
 protein coding gene Chr3:24079357-24187513 (+)
C57BL/6NJ ENSMUSG00215009791
 protein coding gene Chr3:24332620-24434272 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024888
 protein coding gene Chr3:22332295-22394801 (+)
CAST/EiJ ENSTCUG00005025105
 protein coding gene Chr3:23916196-24018050 (+)
CBA/J ENSMUSG00210031859
 protein coding gene Chr3:24065205-24173375 (+)
DBA/2J ENSMUSG00185009431
 protein coding gene Chr3:24300468-24402166 (+)
FVB/NJ ENSMUSG00205008514
 protein coding gene Chr3:23622291-23724001 (+)
JF1/MsJ ENSUMUG00000004741
 protein coding gene Chr3:23776749-23878288 (+)
LP/J ENSMUSG00230001617
 protein coding gene Chr3:26190694-26292400 (+)
NOD/ShiLtJ ENSMUSG00190035012
 protein coding gene Chr3:24359727-24461413 (+)
NZO/HlLtJ ENSMUSG00225007209
 protein coding gene Chr3:28826289-28927952 (+)
PWK/PhJ ENSLUMG00010035909
 protein coding gene Chr3:23753499-23870570 (+)
SPRET/EiJ ENSMSPG00010021994
 protein coding gene Chr3:24127918-24233995 (+)
WSB/EiJ ENSIUOG00005034112
 protein coding gene Chr3:24328496-24430137 (+)



Homology
more
  • Human Ortholog
    NCEH1, neutral cholesterol ester hydrolase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NCEH1, neutral cholesterol ester hydrolase 1
  • Synonyms
    AADACL1, NCEH
  • Links
    NCBI Gene ID: 57552
    UniProt: Q6PIU2

  • Chr Location
    3q26.31; chr3:172630249-172711218 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal organophosphorus metabolism and cholesterol homeostasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    742
  • Tissues
    20
  • cDNA Data
    12
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 320024 NCBI Gene Model | MGI Sequence Detail 61960 C57BL/6J ±  kb
transcript NM_178772 RefSeq | MGI Sequence Detail 4441 C57BL/6  
polypeptide Q8BLF1 UniProt | EBI | MGI Sequence Detail 408 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 7
References
more
  • Summaries
    All 45
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 8
    Phenotypes 16
  • Earliest
    J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory