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Plekhs1 Gene Detail
Summary
  • Symbol
    Plekhs1
  • Name
    pleckstrin homology domain containing S1
  • Synonyms
    9930023K05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443041
    NCBI Gene: 226245
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:56450072-56475184 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 51.86 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    893 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443041
 protein coding gene Chr19:56445705-56475184 (+)
129S1/SvImJ ENSMUSG00200014626
 protein coding gene Chr19:53151072-53176158 (+)
A/J ENSMUSG00195002428
 protein coding gene Chr19:53327780-53352871 (+)
AKR/J ENSMUSG00220017737
 protein coding gene Chr19:53078143-53103277 (+)
BALB/cJ ENSMUSG00180016551
 protein coding gene Chr19:53566874-53591967 (+)
C3H/HeJ ENSMUSG00175021853
 protein coding gene Chr19:53100857-53126018 (+)
C57BL/6NJ ENSMUSG00215021580
 protein coding gene Chr19:53186916-53212004 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023090
 protein coding gene Chr19:52931462-52957782 (+)
CAST/EiJ ENSTCUG00005014912
 protein coding gene Chr19:52722374-52748658 (+)
CBA/J ENSMUSG00210020660
 protein coding gene Chr19:53180169-53205346 (+)
DBA/2J ENSMUSG00185027659
 protein coding gene Chr19:53679023-53704201 (+)
FVB/NJ ENSMUSG00205003512
 protein coding gene Chr19:52587698-52612784 (+)
JF1/MsJ ENSUMUG00000023984
 protein coding gene Chr19:53861002-53887319 (+)
LP/J ENSMUSG00230025199
 protein coding gene Chr19:54432542-54457628 (+)
NOD/ShiLtJ ENSMUSG00190012562
 protein coding gene Chr19:53053980-53079111 (+)
NZO/HlLtJ ENSMUSG00225025016
 protein coding gene Chr19:58038229-58063315 (+)
PWK/PhJ ENSLUMG00010018072
 protein coding gene Chr19:52918059-52944408 (+)
SPRET/EiJ ENSMSPG00010002649
 protein coding gene Chr19:52772034-52799037 (+)
WSB/EiJ ENSIUOG00005023758
 protein coding gene Chr19:52538762-52563969 (+)



Homology
more
  • Human Ortholog
    PLEKHS1, pleckstrin homology domain containing S1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLEKHS1, pleckstrin homology domain containing S1
  • Synonyms
    C10orf81, HEL185
  • Links
    NCBI Gene ID: 79949
    UniProt: Q5SXH7

  • Chr Location
    10q25.3; chr10:113751262-113783429 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    29
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035818 Ensembl Gene Model | MGI Sequence Detail 25113 C57BL/6J ±  kb
transcript ENSMUST00000039666 Ensembl | MGI Sequence Detail 2378 Not Applicable  
polypeptide ENSMUSP00000035440 Ensembl | MGI Sequence Detail 474 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 29
    cDNA 29

    Microarray probesets 2
References
more
  • Summaries
    All 18
    Phenotypes 2
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:339309 Chessa TAM, et al., PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate. Mol Cell. 2023 Aug 17;83(16):2991-3009.e13
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory