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Gramd1c Gene Detail
Summary
  • Symbol
    Gramd1c
  • Name
    GRAM domain containing 1C
  • Synonyms
    4921521N14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443024
    NCBI Gene: 207798
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:43800713-43883708 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 28.44 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2112 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443024
 protein coding gene Chr16:43800713-43883757 (-)
129S1/SvImJ ENSMUSG00200020908
 protein coding gene Chr16:40699125-40782118 (-)
A/J ENSMUSG00195003196
 protein coding gene Chr16:40270394-40353398 (-)
AKR/J ENSMUSG00220021652
 protein coding gene Chr16:40609499-40692501 (-)
BALB/cJ ENSMUSG00180028356
 protein coding gene Chr16:40476914-40559905 (-)
C3H/HeJ ENSMUSG00175024758
 protein coding gene Chr16:40754672-40837666 (-)
C57BL/6NJ ENSMUSG00215006277
 protein coding gene Chr16:40580695-40663690 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020761
 protein coding gene Chr16:40841344-40917069 (-)
CAST/EiJ ENSTCUG00005012762
 protein coding gene Chr16:41011420-41087539 (-)
CBA/J ENSMUSG00210016592
 protein coding gene Chr16:40777434-40860425 (-)
DBA/2J ENSMUSG00185010635
 protein coding gene Chr16:40656646-40739645 (-)
FVB/NJ ENSMUSG00205012192
 protein coding gene Chr16:40609136-40692124 (-)
JF1/MsJ ENSUMUG00000016983
 protein coding gene Chr16:40893988-40969948 (-)
LP/J ENSMUSG00230028851
 protein coding gene Chr16:43252350-43335343 (-)
NOD/ShiLtJ ENSMUSG00190017346
 protein coding gene Chr16:40786412-40869404 (-)
NZO/HlLtJ ENSMUSG00225028374
 protein coding gene Chr16:46338305-46421292 (-)
PWK/PhJ ENSLUMG00010027268
 protein coding gene Chr16:40784928-40869141 (-)
SPRET/EiJ ENSMSPG00010006727
 protein coding gene Chr16:40830038-40907290 (-)
WSB/EiJ ENSIUOG00005012579
 protein coding gene Chr16:40896858-40974237 (-)



Homology
more
  • Human Ortholog
    GRAMD1C, GRAM domain containing 1C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRAMD1C, GRAM domain containing 1C
  • Synonyms
    LAMc
  • Links
    NCBI Gene ID: 54762
    UniProt: Q8IYS0

  • Chr Location
    3q13.31; chr3:113828182-113947179 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and exhibit normal body weight and no significant changes in plasma, liver, or fecal levels of cholesterol and various plant and animal-derived sterols under divergent dietary cholesterol conditions, but do show decreased deoxycholic acid and increased plasma cortisol levels under low dietary cholesterol.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    687
  • Tissues
    27
  • cDNA Data
    6
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036292 Ensembl Gene Model | MGI Sequence Detail 82996 C57BL/6J ±  kb
    transcript ENSMUST00000214098 Ensembl | MGI Sequence Detail 2046 Not Applicable  
    polypeptide ENSMUSP00000150056 Ensembl | MGI Sequence Detail 662 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 3
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:347902 Banerjee R, et al., The nonvesicular sterol transporter Aster-C plays a minor role in whole body cholesterol balance. Front Physiol. 2024;15:1371096
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory