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Eda2r Gene Detail
Summary
  • Symbol
    Eda2r
  • Name
    ectodysplasin A2 receptor
  • Synonyms
    9430060M22Rik, Xedar
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442860
    NCBI Gene: 245527
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:96377446-96420822 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 42.74 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    849 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442860
 protein coding gene ChrX:96375936-96420822 (-)
129S1/SvImJ ENSMUSG00200037446
 protein coding gene ChrX:78096132-78139515 (-)
A/J ENSMUSG00195031564
 protein coding gene ChrX:81867728-81911096 (-)
AKR/J ENSMUSG00220028687
 protein coding gene ChrX:76610981-76654355 (-)
BALB/cJ ENSMUSG00180021609
 protein coding gene ChrX:78586460-78629834 (-)
C3H/HeJ ENSMUSG00175018698
 protein coding gene ChrX:82240176-82283546 (-)
C57BL/6NJ ENSMUSG00215019287
 protein coding gene ChrX:78743387-78786763 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033257
 protein coding gene ChrX:91726706-91769301 (-)
CAST/EiJ ENSTCUG00005028333
 protein coding gene ChrX:79677878-79721427 (-)
CBA/J ENSMUSG00210034707
 protein coding gene ChrX:78987700-79031063 (-)
DBA/2J ENSMUSG00185032018
 protein coding gene ChrX:91435565-91478939 (-)
FVB/NJ ENSMUSG00205023390
 protein coding gene ChrX:78204188-78247551 (-)
JF1/MsJ ENSUMUG00000021836
 protein coding gene ChrX:112054567-112096101 (-)
LP/J ENSMUSG00230012267
 protein coding gene ChrX:98129912-98173272 (-)
NOD/ShiLtJ ENSMUSG00190017139
 protein coding gene ChrX:78124950-78168331 (-)
NZO/HlLtJ ENSMUSG00225045286
 protein coding gene ChrX:103261204-103304582 (-)
PWK/PhJ ENSLUMG00010038671
 protein coding gene ChrX:77348018-77389532 (-)
SPRET/EiJ ENSMSPG00010030270
 protein coding gene ChrX:81522158-81560003 (-)
WSB/EiJ ENSIUOG00005041087
 protein coding gene ChrX:78745491-78788849 (-)



Homology
more
  • Human Ortholog
    EDA2R, ectodysplasin A2 receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EDA2R, ectodysplasin A2 receptor
  • Synonyms
    EDA-A2R, EDAA2R, TNFRSF27, XEDAR
  • Links
    NCBI Gene ID: 60401
    UniProt: Q9HAV5

  • Chr Location
    Xq12; chrX:66594384-66639298 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Hemizygous null males are fertile and healthy with no histological abnormalities in any of the major organs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    655
  • Tissues
    41
  • cDNA Data
    18
  • Literature Summary
    16
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034457 Ensembl Gene Model | MGI Sequence Detail 43377 C57BL/6J ±  kb
transcript ENSMUST00000037353 Ensembl | MGI Sequence Detail 4752 Not Applicable  
polypeptide ENSMUSP00000041210 Ensembl | MGI Sequence Detail 297 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000006887 tumor necrosis factor receptor superfamily member 27
    (term hierarchy)
  • InterPro Domains
    IPR001368 TNFR/NGFR cysteine-rich region
    IPR060024 TNFRSF19/27, second TNFR Cys domain
    IPR034060 Tumor necrosis factor receptor 27, N-terminal
    IPR047526 Tumor necrosis factor receptor superfamily member 19/27/EDAR
    IPR022319 Tumour necrosis factor receptor 27
  • GlyGen
    Q8BX35 2 sites
Molecular
Reagents
less
  • All nucleic 21
    cDNA 18
    Primer pair 2
    Other 1
    Antibodies 3

    Microarray probesets 2
References
more
  • Summaries
    All 53
    Developmental Gene Expression 16
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:77350 Naito A, et al., TRAF6-deficient mice display hypohidrotic ectodermal dysplasia. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8766-71
  • Latest
    J:388147 Xia W, et al., Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair. Nature. 2026 May;653(8115):819-830
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory