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Tmem169 Gene Detail
Summary
  • Symbol
    Tmem169
  • Name
    transmembrane protein 169
  • Synonyms
    A830020B06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442781
    NCBI Gene: 271711
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:72323554-72342263 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 36.48 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    636 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442781
 protein coding gene Chr1:72323528-72342263 (+)
129S1/SvImJ ENSMUSG00200004419
 protein coding gene Chr1:69982005-70000747 (+)
A/J ENSMUSG00195030954
 protein coding gene Chr1:69400356-69418689 (+)
AKR/J ENSMUSG00220035788
 protein coding gene Chr1:69552685-69571062 (+)
BALB/cJ ENSMUSG00180030466
 protein coding gene Chr1:69664316-69683051 (+)
C3H/HeJ ENSMUSG00175000789
 protein coding gene Chr1:69795707-69814042 (+)
C57BL/6NJ ENSMUSG00215011903
 protein coding gene Chr1:69710136-69728878 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014242
 protein coding gene Chr1:65897236-65918902 (+)
CAST/EiJ ENSTCUG00005020329
 protein coding gene Chr1:69461954-69480710 (+)
CBA/J ENSMUSG00210003008
 protein coding gene Chr1:69492307-69511069 (+)
DBA/2J ENSMUSG00185004903
 protein coding gene Chr1:70582874-70601609 (+)
FVB/NJ ENSMUSG00205012949
 protein coding gene Chr1:69218933-69237678 (+)
JF1/MsJ ENSUMUG00000003824
 protein coding gene Chr1:69491695-69509958 (+)
LP/J ENSMUSG00230001530
 protein coding gene Chr1:70577132-70595861 (+)
NOD/ShiLtJ ENSMUSG00190013650
 protein coding gene Chr1:69709159-69727894 (+)
NZO/HlLtJ ENSMUSG00225040112
 protein coding gene Chr1:73792206-73810943 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010018245
 protein coding gene Chr1:71173167-71190404 (+)
WSB/EiJ ENSIUOG00005026835
 protein coding gene Chr1:69360284-69379029 (+)



Homology
more
  • Human Ortholog
    TMEM169, transmembrane protein 169
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM169, transmembrane protein 169
  • Links
    NCBI Gene ID: 92691
    UniProt: Q96HH4

  • Chr Location
    2q35; chr2:216081866-216102783 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    6
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Tmem169
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    13 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    13
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 271711 NCBI Gene Model | MGI Sequence Detail 18710 C57BL/6J ±  kb
transcript NM_001418283 RefSeq | MGI Sequence Detail 3034 C57BL/6  
polypeptide Q8BG50 UniProt | EBI | MGI Sequence Detail 297 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 3
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 13
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:363654 Wang J, et al., Cortex-Specific Tmem169 Deficiency Induces Defects in Cortical Neuron Development and Autism-Like Behaviors in Mice. J Neurosci. 2025 Feb 26;45(9)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory