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Rfx7 Gene Detail
Summary
  • Symbol
    Rfx7
  • Name
    regulatory factor X, 7
  • Synonyms
    2510005N23Rik, 9930116O05Rik, D130086K05Rik, Rfxdc2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442675
    NCBI Gene: 319758
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:72439522-72530111 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 40.08 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1637 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442675
 protein coding gene Chr9:72439346-72530231 (+)
129S1/SvImJ ENSMUSG00200041831
 protein coding gene Chr9:69499826-69590250 (+)
A/J ENSMUSG00195024199
 protein coding gene Chr9:69292098-69383236 (+)
AKR/J ENSMUSG00220038895
 protein coding gene Chr9:69456577-69547826 (+)
BALB/cJ ENSMUSG00180016959
 protein coding gene Chr9:69406493-69497637 (+)
C3H/HeJ ENSMUSG00175011259
 protein coding gene Chr9:69419636-69510770 (+)
C57BL/6NJ ENSMUSG00215014028
 protein coding gene Chr9:69386601-69477307 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032419
 protein coding gene Chr9:69661544-69754049 (+)
CAST/EiJ ENSTCUG00005027952
 protein coding gene Chr9:69232282-69321695 (+)
CBA/J ENSMUSG00210013592
 protein coding gene Chr9:69500215-69591460 (+)
DBA/2J ENSMUSG00185031478
 protein coding gene Chr9:69524076-69615216 (+)
FVB/NJ ENSMUSG00205023587
 protein coding gene Chr9:69797462-69888707 (+)
JF1/MsJ ENSUMUG00000034872
 protein coding gene Chr9:69575231-69665165 (+)
LP/J ENSMUSG00230025994
 protein coding gene Chr9:69694804-69785227 (+)
NOD/ShiLtJ ENSMUSG00190020855
 protein coding gene Chr9:69628114-69719251 (+)
NZO/HlLtJ ENSMUSG00225045115
 protein coding gene Chr9:69830654-69921897 (+)
PWK/PhJ ENSLUMG00010023794
 protein coding gene Chr9:69492225-69582062 (+)
SPRET/EiJ ENSMSPG00010017742
 protein coding gene Chr9:70593520-70682454 (+)
WSB/EiJ ENSIUOG00005026172
 protein coding gene Chr9:69005638-69095968 (+)



Homology
more
  • Human Ortholog
    RFX7, regulatory factor X7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RFX7, regulatory factor X7
  • Synonyms
    MRD71, RFXDC2
  • Links
    NCBI Gene ID: 64864
    UniProt: Q2KHR2

  • Chr Location
    15q21.3; chr15:56087280-56245103 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RFX7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit incomplete preweaning lethality. Mice homozygous for a null allele activated in hematopoietic cells exhibit decreased NK cell maintenance and immunity in vivo and increased NK cell size, granularity, proliferation, and energetic state.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    762
  • Tissues
    138
  • cDNA Data
    109
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037674 Ensembl Gene Model | MGI Sequence Detail 90590 C57BL/6J ±  kb
    transcript ENSMUST00000163401 Ensembl | MGI Sequence Detail 7880 Not Applicable  
    polypeptide ENSMUSP00000127192 Ensembl | MGI Sequence Detail 1459 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 113
      cDNA 109
      Primer pair 2
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1924254, MGI:2442903
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:385405 Hermant C, et al., TBP regulates transposable element expression in early mouse embryos. EMBO J. 2026 May;45(9):3073-3101
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory