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Ints15 Gene Detail
Summary
  • Symbol
    Ints15
  • Name
    integrator complex subunit 15
  • Synonyms
    E130309D02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442621
    NCBI Gene: 231868
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:143286950-143301115 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 82.07 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    457 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442621
 protein coding gene Chr5:143286827-143301147 (-)
129S1/SvImJ ENSMUSG00200039981
 protein coding gene Chr5:137154742-137169328 (-)
A/J ENSMUSG00195038936
 protein coding gene Chr5:136799174-136813781 (-)
AKR/J ENSMUSG00220021698
 protein coding gene Chr5:136032171-136046755 (-)
BALB/cJ ENSMUSG00180032570
 protein coding gene Chr5:136901222-136915818 (-)
C3H/HeJ ENSMUSG00175036386
 protein coding gene Chr5:138826735-138841335 (-)
C57BL/6NJ ENSMUSG00215040369
 protein coding gene Chr5:136735354-136749948 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027977
 protein coding gene Chr5:136025764-136040026 (-)
CAST/EiJ ENSTCUG00005027217
 protein coding gene Chr5:136182504-136197150 (-)
CBA/J ENSMUSG00210023427
 protein coding gene Chr5:137633598-137648175 (-)
DBA/2J ENSMUSG00185051182
 protein coding gene Chr5:140628441-140643025 (-)
FVB/NJ ENSMUSG00205029254
 protein coding gene Chr5:136452906-136467494 (-)
JF1/MsJ ENSUMUG00000033443
 protein coding gene Chr5:143510500-143525065 (-)
LP/J ENSMUSG00230026437
 protein coding gene Chr5:144758494-144773076 (-)
NOD/ShiLtJ ENSMUSG00190034859
 protein coding gene Chr5:136591710-136606292 (-)
NZO/HlLtJ ENSMUSG00225023052
 protein coding gene Chr5:152225966-152240556 (-)
PWK/PhJ ENSLUMG00010018949
 protein coding gene Chr5:135216498-135231028 (-)
SPRET/EiJ ENSMSPG00010025668
 protein coding gene Chr5:138826394-138840732 (-)
WSB/EiJ ENSIUOG00005030118
 protein coding gene Chr5:139117104-139131672 (-)



Homology
more
  • Human Ortholog
    INTS15, integrator complex subunit 15
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INTS15, integrator complex subunit 15
  • Synonyms
    C7orf26
  • Links
    NCBI Gene ID: 79034
    UniProt: Q96N11

  • Chr Location
    7p22.1; chr7:6589978-6608726 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 3 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a deletion in exon 2 are embryonic lethal while heterozygotes show severe ocular malformations, including persistence of fetal vasculature, chorioretinal atrophy, corneal opacity, cataract and optic nerve anomaly. Mice with a heterozygous or homozygous deletion in exon 6 exhibit milder eye phenotypes at a lower incidence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    6
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    777
  • Tissues
    25
  • cDNA Data
    52
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039244 Ensembl Gene Model | MGI Sequence Detail 14166 C57BL/6J ±  kb
    transcript ENSMUST00000046418 Ensembl | MGI Sequence Detail 2208 Not Applicable  
    polypeptide ENSMUSP00000041800 Ensembl | MGI Sequence Detail 448 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      cDNA 52
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:6885575, MGI:7276233
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 6
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:337973 Azuma N, et al., Integrator complex subunit 15 controls mRNA splicing and is critical for eye development. Hum Mol Genet. 2023 Jun 5;32(12):2032-2045
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory