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Cers6 Gene Detail
Summary
  • Symbol
    Cers6
  • Name
    ceramide synthase 6
  • Synonyms
    4732462C07Rik, CerS6, Lass6, similar to TRH1, T1L
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442564
    NCBI Gene: 241447
  • Alliance
  • Transcription Start Sites
    62 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:68691785-68944626 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 39.53 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7035 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442564
protein coding gene Chr2:68691489-68944628 (+)
129S1/SvImJ ENSMUSG00200035862
protein coding gene Chr2:65744189-65992542 (+)
A/J ENSMUSG00195020750
protein coding gene Chr2:65889298-66137441 (+)
AKR/J ENSMUSG00220035958
protein coding gene Chr2:65856417-66104537 (+)
BALB/cJ ENSMUSG00180040587
protein coding gene Chr2:65848133-66100991 (+)
C3H/HeJ ENSMUSG00175031496
protein coding gene Chr2:65956433-66209289 (+)
C57BL/6NJ ENSMUSG00215026195
protein coding gene Chr2:65787438-66040302 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023615
protein coding gene Chr2:63377269-63626424 (+)
CAST/EiJ ENSTCUG00005008432
protein coding gene Chr2:65248699-65494156 (+)
CBA/J ENSMUSG00210032907
protein coding gene Chr2:65996712-66249560 (+)
DBA/2J ENSMUSG00185038003
protein coding gene Chr2:65843374-66096208 (+)
FVB/NJ ENSMUSG00205023335
protein coding gene Chr2:65304254-65552379 (+)
JF1/MsJ ENSUMUG00000003038
protein coding gene Chr2:65505882-65756215 (+)
LP/J ENSMUSG00230019067
protein coding gene Chr2:67648932-67901762 (+)
NOD/ShiLtJ ENSMUSG00190036239
protein coding gene Chr2:65926608-66174599 (+)
NZO/HlLtJ ENSMUSG00225015097
protein coding gene Chr2:75385574-75633687 (+)
PWK/PhJ ENSLUMG00010031716
protein coding gene Chr2:65720413-65974064 (+)
SPRET/EiJ ENSMSPG00010032897
protein coding gene Chr2:67079260-67334645 (+)
WSB/EiJ ENSIUOG00005017406
protein coding gene Chr2:65974845-66221666 (+)



Homology
more
  • Human Ortholog
    CERS6, ceramide synthase 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CERS6, ceramide synthase 6
  • Synonyms
    LASS6
  • Links
    NCBI Gene ID: 253782
    UniProt: Q6ZMG9

  • Chr Location
    2q24.3; chr2:168456249-168775134 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 4 genetic backgrounds
    1 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele exhibit hind limb clasping, habituation deficit and altered lipid homeostasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027035 Ensembl Gene Model | MGI Sequence Detail 252842 C57BL/6J ±  kb
    transcript ENSMUST00000176018 Ensembl | MGI Sequence Detail 1279 Not Applicable  
    polypeptide ENSMUSP00000135604 Ensembl | MGI Sequence Detail 392 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 12
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2139372
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 8
      Gene Ontology 13
      Phenotypes 24
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:372685 Kassir MF, et al., Alzheimer's Disease-Associated Amyloid-beta Precursor Protein Prevents Aging Stress-Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity. Cancer Res. 2025 Oct 1;85(19):3791-3811

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    09/08/2026
    MGI 6.24
    The Jackson Laboratory