About   Help   FAQ
Prrg4 Gene Detail
Summary
  • Symbol
    Prrg4
  • Name
    proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
  • Synonyms
    9930111I18Rik, TMG4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442211
    NCBI Gene: 228413
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:104661086-104680221 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 54.98 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    642 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442211
 protein coding gene Chr2:104657374-104680221 (-)
129S1/SvImJ ENSMUSG00200007392
 protein coding gene Chr2:101483745-101502791 (-)
A/J ENSMUSG00195029670
 protein coding gene Chr2:101641247-101660545 (-)
AKR/J ENSMUSG00220001580
 protein coding gene Chr2:101392291-101411592 (-)
BALB/cJ ENSMUSG00180030858
 protein coding gene Chr2:101442306-101461605 (-)
C3H/HeJ ENSMUSG00175027552
 protein coding gene Chr2:101734199-101753162 (-)
C57BL/6NJ ENSMUSG00215014066
 protein coding gene Chr2:101545964-101565078 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024031
 protein coding gene Chr2:98305812-98325103 (-)
CAST/EiJ ENSTCUG00005001536
 protein coding gene Chr2:100813710-100832729 (-)
CBA/J ENSMUSG00210033151
 protein coding gene Chr2:101720055-101739357 (-)
DBA/2J ENSMUSG00185005562
 protein coding gene Chr2:101439040-101458344 (-)
FVB/NJ ENSMUSG00205010263
 protein coding gene Chr2:100765980-100785153 (-)
JF1/MsJ ENSUMUG00000025012
 protein coding gene Chr2:101143566-101162536 (-)
LP/J ENSMUSG00230005774
 protein coding gene Chr2:103188331-103207630 (-)
NOD/ShiLtJ ENSMUSG00190015523
 protein coding gene Chr2:101565049-101584107 (-)
NZO/HlLtJ ENSMUSG00225008180
 protein coding gene Chr2:111094483-111113613 (-)
PWK/PhJ ENSLUMG00010023180
 protein coding gene Chr2:101147031-101165993 (-)
SPRET/EiJ ENSMSPG00010033717
 protein coding gene Chr2:103193417-103211094 (-)
WSB/EiJ ENSIUOG00005001242
 protein coding gene Chr2:101244741-101261307 (-)



Homology
more
  • Human Ortholog
    PRRG4, proline rich and Gla domain 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRRG4, proline rich and Gla domain 4
  • Synonyms
    PRGP4, TMG4
  • Links
    NCBI Gene ID: 79056
    UniProt: Q9BZD6

  • Chr Location
    11p13; chr11:32829675-32858120 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027171 Ensembl Gene Model | MGI Sequence Detail 19136 C57BL/6J ±  kb
    transcript ENSMUST00000028593 Ensembl | MGI Sequence Detail 2872 Not Applicable  
    polypeptide ENSMUSP00000028593 Ensembl | MGI Sequence Detail 226 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000013315 transmembrane gamma-carboxyglutamic acid protein 4
      (term hierarchy)
    • InterPro Domains
      IPR017857 Coagulation factor-like, Gla domain superfamily
      IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
      IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
      IPR050442 Peptidase S1 family, coagulation factors
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 2
    References
    more
    • Summaries
      All 40
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory