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Bank1 Gene Detail
Summary
  • Symbol
    Bank1
  • Name
    B cell scaffold protein with ankyrin repeats 1
  • Synonyms
    A530094C12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442120
    NCBI Gene: 242248
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:135759124-136031827 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 63.04 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8168 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442120
 protein coding gene Chr3:135759124-136031902 (-)
129S1/SvImJ ENSMUSG00200002298
 protein coding gene Chr3:132536567-132810669 (-)
A/J ENSMUSG00195004006
 protein coding gene Chr3:132657334-132924091 (-)
AKR/J ENSMUSG00220022069
 protein coding gene Chr3:131119813-131386942 (-)
BALB/cJ ENSMUSG00180011396
 protein coding gene Chr3:132579108-132845440 (-)
C3H/HeJ ENSMUSG00175019546
 protein coding gene Chr3:132179961-132446709 (-)
C57BL/6NJ ENSMUSG00215019322
 protein coding gene Chr3:132917106-133189847 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025663
 protein coding gene Chr3:129295287-129556690 (-)
CAST/EiJ ENSTCUG00005003656
 protein coding gene Chr3:133255586-133529497 (-)
CBA/J ENSMUSG00210029479
 protein coding gene Chr3:132776935-133039334 (-)
DBA/2J ENSMUSG00185003455
 protein coding gene Chr3:133414569-133676970 (-)
FVB/NJ ENSMUSG00205024994
 protein coding gene Chr3:131728504-131990919 (-)
JF1/MsJ ENSUMUG00000015964
 protein coding gene Chr3:132161825-132432591 (-)
LP/J ENSMUSG00230002534
 protein coding gene Chr3:135350517-135624596 (-)
NOD/ShiLtJ ENSMUSG00190004158
 protein coding gene Chr3:133793478-134055849 (-)
NZO/HlLtJ ENSMUSG00225004532
 protein coding gene Chr3:137838365-138105488 (-)
PWK/PhJ ENSLUMG00010015264
 protein coding gene Chr3:132094042-132354055 (-)
SPRET/EiJ ENSMSPG00010014069
 protein coding gene Chr3:133198616-133466959 (-)
WSB/EiJ ENSIUOG00005017332
 protein coding gene Chr3:132930538-133204848 (-)



Homology
more
  • Human Ortholog
    BANK1, B cell scaffold protein with ankyrin repeats 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BANK1, B cell scaffold protein with ankyrin repeats 1
  • Synonyms
    BANK
  • Links
    NCBI Gene ID: 55024
    UniProt: Q8NDB2

  • Chr Location
    4q24; chr4:101411286-102074812 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with human BANK1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased germinal center formation and IgM production in response to T-dependent antigens, and show enhanced CD40-mediated B cell proliferative and survival responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037922 Ensembl Gene Model | MGI Sequence Detail 272704 C57BL/6J ±  kb
    transcript ENSMUST00000041577 Ensembl | MGI Sequence Detail 3268 Not Applicable  
    polypeptide ENSMUSP00000035484 Ensembl | MGI Sequence Detail 783 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000004639 B-cell scaffold protein with ankyrin repeats
      (term hierarchy)
    • InterPro Domains
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR052446 BANK1, PIK3AP1 and Stumps
      IPR017893 DBB domain
      IPR041340 PIK3AP1, Toll/interleukin-1 receptor domain
      IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
      IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
    • GlyGen
      Q80VH0 1 site
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 28

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139723
    References
    more
    • Summaries
      All 45
      Diseases 1
      Gene Ontology 9
      Phenotypes 13
    • Earliest
      J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
    • Latest
      J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory