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Hmgxb3 Gene Detail
Summary
  • Symbol
    Hmgxb3
  • Name
    HMG box domain containing 3
  • Synonyms
    2510002C16Rik, A630042L21Rik, mKIAA0194
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441817
    NCBI Gene: 106894
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:61264349-61310122 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 34.41 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1193 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441817
 protein coding gene Chr18:61264349-61310122 (-)
129S1/SvImJ ENSMUSG00200033168
 protein coding gene Chr18:58429121-58470151 (-)
A/J ENSMUSG00195005314
 protein coding gene Chr18:58494988-58536627 (-)
AKR/J ENSMUSG00220016256
 protein coding gene Chr18:58480592-58522417 (-)
BALB/cJ ENSMUSG00180012299
 protein coding gene Chr18:59062107-59103739 (-)
C3H/HeJ ENSMUSG00175034002
 protein coding gene Chr18:58677089-58718099 (-)
C57BL/6NJ ENSMUSG00215038947
 protein coding gene Chr18:57996970-58037989 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022320
 protein coding gene Chr18:57925622-57971740 (-)
CAST/EiJ ENSTCUG00005025693
 protein coding gene Chr18:57698312-57739891 (-)
CBA/J ENSMUSG00210032146
 protein coding gene Chr18:58624747-58666378 (-)
DBA/2J ENSMUSG00185015111
 protein coding gene Chr18:58524367-58565376 (-)
FVB/NJ ENSMUSG00205015394
 protein coding gene Chr18:58009361-58050374 (-)
JF1/MsJ ENSUMUG00000021357
 protein coding gene Chr18:58398522-58440019 (-)
LP/J ENSMUSG00230009978
 protein coding gene Chr18:60588746-60629778 (-)
NOD/ShiLtJ ENSMUSG00190023822
 protein coding gene Chr18:58278348-58320176 (-)
NZO/HlLtJ ENSMUSG00225035272
 protein coding gene Chr18:60460760-60508182 (-)
PWK/PhJ ENSLUMG00010007677
 protein coding gene Chr18:58808929-58850464 (-)
SPRET/EiJ ENSMSPG00010017041
 protein coding gene Chr18:59053820-59100225 (-)
WSB/EiJ ENSIUOG00005009123
 protein coding gene Chr18:58151372-58192335 (-)



Homology
more
  • Human Ortholog
    HMGXB3, HMG-box containing 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HMGXB3, HMG-box containing 3
  • Synonyms
    HMGX3, SMF
  • Links
    NCBI Gene ID: 22993
    UniProt: Q12766

  • Chr Location
    5q32; chr5:150000046-150053142 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    651
  • Tissues
    50
  • cDNA Data
    14
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 106894 NCBI Gene Model | MGI Sequence Detail 45774 C57BL/6J ±  kb
    transcript NM_178277 RefSeq | MGI Sequence Detail 5211 C57BL/6  
    polypeptide NP_840061 RefSeq | MGI Sequence Detail 1286 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • InterPro Domains
      IPR009071 High mobility group box domain
      IPR036910 High mobility group box domain superfamily
      IPR039598 HMG domain-containing protein 3
      IPR040648 HMG domain-containing protein 3, CxC4 like cysteine cluster
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1919564, MGI:2147216
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 5
      Gene Ontology 2
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory