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Lgr6 Gene Detail
Summary
  • Symbol
    Lgr6
  • Name
    leucine-rich repeat-containing G protein-coupled receptor 6
  • Synonyms
    A530037C04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441805
    NCBI Gene: 329252
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:134911039-135033014 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 58.24 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3344 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441805
 protein coding gene Chr1:134911038-135033112 (-)
129S1/SvImJ ENSMUSG00200008866
 protein coding gene Chr1:132524902-132647092 (-)
A/J ENSMUSG00195041180
 protein coding gene Chr1:131599390-131721708 (-)
AKR/J ENSMUSG00220048031
 protein coding gene Chr1:131477489-131599621 (-)
BALB/cJ ENSMUSG00180035065
 protein coding gene Chr1:132138939-132260906 (-)
C3H/HeJ ENSMUSG00175036907
 protein coding gene Chr1:131843579-131965885 (-)
C57BL/6NJ ENSMUSG00215045191
 protein coding gene Chr1:131840643-131962659 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014630
 protein coding gene Chr1:126586353-126709738 (-)
CAST/EiJ ENSTCUG00005031901
 protein coding gene Chr1:130761603-130883656 (-)
CBA/J ENSMUSG00210026212
 protein coding gene Chr1:131774189-131896321 (-)
DBA/2J ENSMUSG00185027736
 protein coding gene Chr1:136148731-136270827 (-)
FVB/NJ ENSMUSG00205043628
 protein coding gene Chr1:131109808-131231980 (-)
JF1/MsJ ENSUMUG00000032804
 protein coding gene Chr1:135271962-135393945 (-)
LP/J ENSMUSG00230034850
 protein coding gene Chr1:135673682-135795639 (-)
NOD/ShiLtJ ENSMUSG00190039592
 protein coding gene Chr1:131788314-131910429 (-)
NZO/HlLtJ ENSMUSG00225018547
 protein coding gene Chr1:139439445-139561822 (-)
PWK/PhJ ENSLUMG00010022654
 protein coding gene Chr1:130897319-131018962 (-)
SPRET/EiJ ENSMSPG00010011368
 protein coding gene Chr1:133699305-133820898 (-)
WSB/EiJ ENSIUOG00005043087
 protein coding gene Chr1:131531592-131653734 (-)



Homology
more
  • Human Ortholog
    LGR6, leucine rich repeat containing G protein-coupled receptor 6
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LGR6, leucine rich repeat containing G protein-coupled receptor 6
  • Synonyms
    GPCR, VTS20631
  • Links
    NCBI Gene ID: 59352
    UniProt: Q9HBX8

  • Chr Location
    1q32.1; chr1:202193692-202319781 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter/null allele are viable and fertile with no apparent abnormal phenotype. Similarly, mice homozygous for a knock-in allele are healthy and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    811
  • Tissues
    83
  • cDNA Data
    21
  • Literature Summary
    29
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042793 Ensembl Gene Model | MGI Sequence Detail 121976 C57BL/6J ±  kb
    transcript ENSMUST00000044828 Ensembl | MGI Sequence Detail 6675 Not Applicable  
    polypeptide ENSMUSP00000035444 Ensembl | MGI Sequence Detail 967 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000001593 leucine-rich repeat-containing G-protein coupled receptor 6
      (term hierarchy)
    • InterPro Domains
      IPR002131 Glycoprotein hormone receptor family
      IPR000276 G protein-coupled receptor, rhodopsin-like
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR000372 Leucine-rich repeat N-terminal domain
      IPR003591 Leucine-rich repeat, typical subtype
    • GlyGen
      Q3UVD5 2 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 2
      cDNA 21
      Primer pair 8
      Other 5
      Antibodies 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 121
      Developmental Gene Expression 29
      Gene Ontology 8
      Phenotypes 64
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:388805 Kandyba E, et al., Chemically induced skin tumors arise from long-lived stem cells of the upper hair follicle. Science. 2026 Jun 11;:eadv8291
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory