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Gpr61 Gene Detail
Summary
  • Symbol
    Gpr61
  • Name
    G protein-coupled receptor 61
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441719
    NCBI Gene: 229714
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:108055660-108062218 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 46.84 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    181 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441719
 protein coding gene Chr3:108055637-108062218 (-)
129S1/SvImJ ENSMUSG00200034453
 protein coding gene Chr3:104671621-104678182 (-)
A/J ENSMUSG00195024158
 protein coding gene Chr3:105098054-105104616 (-)
AKR/J ENSMUSG00220030061
 protein coding gene Chr3:103461693-103468254 (-)
BALB/cJ ENSMUSG00180017865
 protein coding gene Chr3:105043379-105049939 (-)
C3H/HeJ ENSMUSG00175029532
 protein coding gene Chr3:104578170-104584731 (-)
C57BL/6NJ ENSMUSG00215025630
 protein coding gene Chr3:105306041-105312602 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025521
 protein coding gene Chr3:102359714-102366466 (-)
CAST/EiJ ENSTCUG00005025643
 protein coding gene Chr3:105577105-105583665 (-)
CBA/J ENSMUSG00210007206
 protein coding gene Chr3:105200036-105206597 (-)
DBA/2J ENSMUSG00185021346
 protein coding gene Chr3:105669370-105675931 (-)
FVB/NJ ENSMUSG00205023310
 protein coding gene Chr3:104236037-104242599 (-)
JF1/MsJ ENSUMUG00000004325
 protein coding gene Chr3:104644721-104651280 (-)
LP/J ENSMUSG00230014819
 protein coding gene Chr3:107584617-107591178 (-)
NOD/ShiLtJ ENSMUSG00190026165
 protein coding gene Chr3:105907457-105914018 (-)
NZO/HlLtJ ENSMUSG00225016547
 protein coding gene Chr3:110090975-110096864 (-)
PWK/PhJ ENSLUMG00010022979
 protein coding gene Chr3:104508058-104514618 (-)
SPRET/EiJ ENSMSPG00010031691
 protein coding gene Chr3:105008953-105012563 (-)
WSB/EiJ ENSIUOG00005004044
 protein coding gene Chr3:105221897-105228458 (-)



Homology
more
  • Human Ortholog
    GPR61, G protein-coupled receptor 61
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR61, G protein-coupled receptor 61
  • Synonyms
    BALGR, GPCR3
  • Links
    NCBI Gene ID: 83873
    UniProt: Q9BZJ8

  • Chr Location
    1p13.3; chr1:109539872-109548406 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit hyperphagia, obesity, increased liver weight and liver triglyceride content, increased visceral fat pad weight, and increased circulating insulin and leptin levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    598
  • Tissues
    1
  • cDNA Data
    9
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 229714 NCBI Gene Model | MGI Sequence Detail 6559 C57BL/6J ±  kb
    transcript NM_001411298 RefSeq | MGI Sequence Detail 3683 C57BL/6  
    polypeptide Q8C010 UniProt | EBI | MGI Sequence Detail 449 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 2
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
    • Latest
      J:369750 Tchio C, et al., An integrative approach prioritizes the orphan GPR61 genomic region in tissue-specific regulation of chronotype. Sleep Adv. 2025 Apr;6(2):zpaf030
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory