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Tlk1 Gene Detail
Summary
  • Symbol
    Tlk1
  • Name
    tousled-like kinase 1
  • Synonyms
    4930545J15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441683
    NCBI Gene: 228012
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:70542751-70656072 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 41.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1923 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441683
 protein coding gene Chr2:70542751-70656505 (-)
129S1/SvImJ ENSMUSG00200036642
 protein coding gene Chr2:67603325-67716501 (-)
A/J ENSMUSG00195019764
 protein coding gene Chr2:67753084-67866291 (-)
AKR/J ENSMUSG00220038461
 protein coding gene Chr2:67717837-67831027 (-)
BALB/cJ ENSMUSG00180038711
 protein coding gene Chr2:67701471-67814675 (-)
C3H/HeJ ENSMUSG00175034686
 protein coding gene Chr2:67820514-67933695 (-)
C57BL/6NJ ENSMUSG00215022580
 protein coding gene Chr2:67639740-67752915 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023638
 protein coding gene Chr2:65250797-65362332 (-)
CAST/EiJ ENSTCUG00005008480
 protein coding gene Chr2:67125007-67244512 (-)
CBA/J ENSMUSG00210035842
 protein coding gene Chr2:67860782-67973953 (-)
DBA/2J ENSMUSG00185037632
 protein coding gene Chr2:67696383-67809581 (-)
FVB/NJ ENSMUSG00205035674
 protein coding gene Chr2:67163604-67276789 (-)
JF1/MsJ ENSUMUG00000003907
 protein coding gene Chr2:67359059-67472511 (-)
LP/J ENSMUSG00230021229
 protein coding gene Chr2:69501785-69614966 (-)
NOD/ShiLtJ ENSMUSG00190027705
 protein coding gene Chr2:67786299-67899475 (-)
NZO/HlLtJ ENSMUSG00225014409
 protein coding gene Chr2:77244061-77357245 (-)
PWK/PhJ ENSLUMG00010031025
 protein coding gene Chr2:67588166-67701653 (-)
SPRET/EiJ ENSMSPG00010033810
 protein coding gene Chr2:68991840-69105150 (-)
WSB/EiJ ENSIUOG00005017498
 protein coding gene Chr2:67837774-67951123 (-)



Homology
more
  • Human Ortholog
    TLK1, tousled like kinase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLK1, tousled like kinase 1
  • Synonyms
    PKU-beta
  • Links
    NCBI Gene ID: 9874
    UniProt: Q9UKI8

  • Chr Location
    2q31.1; chr2:170990823-171231314 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and fertile with no overt phenotypes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    635
  • Tissues
    31
  • cDNA Data
    129
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041997 Ensembl Gene Model | MGI Sequence Detail 113322 C57BL/6J ±  kb
    transcript ENSMUST00000038584 Ensembl | MGI Sequence Detail 4280 Not Applicable  
    polypeptide ENSMUSP00000035961 Ensembl | MGI Sequence Detail 766 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000016377 serine/threonine-protein kinase tousled-like 1
      (term hierarchy)
    • EC
      2.7.11.1
    • InterPro Domains
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
    • GlyGen
      Q8C0V0 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 130
      cDNA 129
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 19
    • Earliest
      J:53339 Shalom S, et al., Tlk, a novel evolutionarily conserved murine serine threonine kinase, encodes multiple testis transcripts. Mol Reprod Dev. 1999 Apr;52(4):392-405
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory