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Mrgprb2 Gene Detail
Summary
  • Symbol
    Mrgprb2
  • Name
    MAS-related GPR, member B2
  • Synonyms
    4833406I20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441674
    NCBI Gene: 243979
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:48200713-48207834 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 31.11 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    232 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441674
 protein coding gene Chr7:48200713-48207834 (-)
129S1/SvImJ ENSMUSG00200023353
 protein coding gene Chr7:35815021-35822142 (-)
A/J ENSMUSG00195045427
 protein coding gene Chr7:39831139-39838260 (-)
AKR/J ENSMUSG00220008150
 protein coding gene Chr7:34120990-34128110 (-)
BALB/cJ ENSMUSG00180033508
 protein coding gene Chr7:36714930-36722053 (-)
C3H/HeJ ENSMUSG00175027711
 protein coding gene Chr7:37288379-37295500 (-)
C57BL/6NJ ENSMUSG00215039080
 protein coding gene Chr7:36497897-36505021 (-)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005041993
 protein coding gene Chr7:40343927-40351012 (-)
CBA/J ENSMUSG00210036186
 protein coding gene Chr7:37599580-37606700 (-)
DBA/2J ENSMUSG00185027784
 protein coding gene Chr7:41497935-41505056 (-)
FVB/NJ ENSMUSG00205045697
 protein coding gene Chr7:37244887-37251979 (-)
JF1/MsJ ENSUMUG00000051286
 protein coding gene Chr7:46263580-46270660 (-)
LP/J ENSMUSG00230051313
 protein coding gene Chr7:47013195-47020316 (-)
NOD/ShiLtJ ENSMUSG00190046361
 protein coding gene Chr7:37585652-37592744 (-)
NZO/HlLtJ ENSMUSG00225012537
 protein coding gene Chr7:45125347-45132468 (-)
PWK/PhJ ENSLUMG00010041044
 protein coding gene Chr7:36360922-36367997 (-)
SPRET/EiJ ENSMSPG00010035909
 protein coding gene Chr7:36163464-36176238 (-)
WSB/EiJ ENSIUOG00005026565
 protein coding gene Chr7:37936111-37943202 (-)



Homology
more
  • Human Ortholog
    MRGPRX2, MAS related GPR family member X2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MRGPRX2, MAS related GPR family member X2
  • Synonyms
    MGRG3, MRGX2
  • Links
    NCBI Gene ID: 117194
    UniProt: Q96LB1

  • Chr Location
    11p15.1; chr11:19054455-19060717 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired mast cell activation and inflammatory response after treatment with compound 48/80.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 243979 NCBI Gene Model | MGI Sequence Detail 7122 C57BL/6J ±  kb
    transcript NM_175531 RefSeq | MGI Sequence Detail 2089 C57BL/6  
    polypeptide Q3KNA1 UniProt | EBI | MGI Sequence Detail 338 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR017452 GPCR, rhodopsin-like, 7TM
      IPR000276 G protein-coupled receptor, rhodopsin-like
      IPR026234 Mas-related G protein-coupled receptor family
    • GlyGen
      Q3KNA1 3 sites
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 2
    References
    more
    • Summaries
      All 63
      Gene Ontology 8
      Phenotypes 34
    • Earliest
      J:71586 Dong X, et al., A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell. 2001 Sep 7;106(5):619-32
    • Latest
      J:389439 Xu H, et al., Fibroblast MrgprX2/B2 signaling drives hypertrophic scar fibrosis. Cell Rep. 2026 Jun 25;45(7):117616
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory