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Nags Gene Detail
Summary
  • Symbol
    Nags
  • Name
    N-acetylglutamate synthase
  • Synonyms
    1700120E20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387600
    NCBI Gene: 217214
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:102036339-102040303 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 65.48 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    166 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2387600
 protein coding gene Chr11:102036339-102040354 (+)
129S1/SvImJ ENSMUSG00200049582
 protein coding gene Chr11:99322819-99328593 (+)
A/J ENSMUSG00195051950
 protein coding gene Chr11:99018513-99024299 (+)
AKR/J ENSMUSG00220050936
 protein coding gene Chr11:99238247-99244023 (+)
BALB/cJ ENSMUSG00180049526
 protein coding gene Chr11:99370456-99376230 (+)
C3H/HeJ ENSMUSG00175046066
 protein coding gene Chr11:99296316-99302090 (+)
C57BL/6NJ ENSMUSG00215052538
 protein coding gene Chr11:98857893-98863679 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017239
 protein coding gene Chr11:98082794-98086740 (+)
CAST/EiJ ENSTCUG00005047143
 protein coding gene Chr11:98791662-98797448 (+)
CBA/J ENSMUSG00210053129
 protein coding gene Chr11:99003730-99009517 (+)
DBA/2J ENSMUSG00185046794
 protein coding gene Chr11:99346188-99351964 (+)
FVB/NJ ENSMUSG00205044861
 protein coding gene Chr11:99188620-99194407 (+)
JF1/MsJ ENSUMUG00000049076
 protein coding gene Chr11:99605849-99612812 (+)
LP/J ENSMUSG00230048131
 protein coding gene Chr11:100398757-100404531 (+)
NOD/ShiLtJ ENSMUSG00190042415
 protein coding gene Chr11:99385073-99390846 (+)
NZO/HlLtJ ENSMUSG00225050570
 protein coding gene Chr11:102421507-102427280 (+)
PWK/PhJ ENSLUMG00010042724
 protein coding gene Chr11:99138988-99145918 (+)
SPRET/EiJ ENSMSPG00010049340
 protein coding gene Chr11:99638560-99644349 (+)
WSB/EiJ ENSIUOG00005049957
 protein coding gene Chr11:99139319-99145102 (+)



Homology
more
  • Human Ortholog
    NAGS, N-acetylglutamate synthase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NAGS, N-acetylglutamate synthase
  • Synonyms
    AGAS, ARGA
  • Links
    NCBI Gene ID: 162417
    UniProt: Q8N159

  • Chr Location
    17q21.31; chr17:44004581-44011028 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human NAGS associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
In the absence of N-carbamyl-L-glutamate and L-citrulline supplementation homozygous null mice develop severe hyperammonemia and die.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    691
  • Tissues
    94
  • cDNA Data
    16
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048217 Ensembl Gene Model | MGI Sequence Detail 3965 C57BL/6J ±  kb
    transcript ENSMUST00000055409 Ensembl | MGI Sequence Detail 2028 Not Applicable  
    polypeptide ENSMUSP00000050258 Ensembl | MGI Sequence Detail 527 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1920851, MGI:2144153
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 1
      Gene Ontology 11
      Phenotypes 12
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory